COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction.
COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction.
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DOI：
10.3389/fonc.2022.1049345
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发表时间：
2022
影响因子：
4.7
通讯作者：
Zhang, Qingling
中科院分区：
文献类型：
--
作者：
Wen, Zhihui;Sun, Jingbo;Luo, Junjie;Fu, Yun;Qiu, Yue;Li, Yanyan;Xu, Yangwei;Wu, Hongmei;Zhang, Qingling
胰腺导管腺癌（Pancreatic ductal adencarcinoma， PDAC）是最致命的恶性肿瘤之一，预后较差。X型胶原α 1链（COL10A1）是胶原家族成员，是与多种人类肿瘤进展相关的基因，但COL10A1在胰腺癌中的具体功能和分子机制尚不清楚。我们的研究发现，COL10A1在胰腺癌细胞和组织中高表达，其高表达与预后不良及肿瘤大小、分化等一些临床病理特征有关。生物学功能实验表明，过表达COL10A1可增强PDAC细胞的增殖和迁移能力。有趣的是，COL10A1的受体盘状蛋白结构域受体2 （DDR2）受COL10A1调控。我们发现COL10A1-DDR2轴激活丝裂原活化蛋白激酶(MEK)/细胞外信号调节激酶（ERK）通路，导致上皮-间质转化（EMT）并加速胰腺癌的进展。综上所述，COL10A1通过与DDR2结合，调控PDAC细胞增殖和MEK/ERK信号通路，促进迁移、侵袭和EMT。我们的研究表明COL10A1可能是促进PDAC进展的关键因素。需要更多的研究来证实COL10A1作为PDAC的潜在生物标志物和治疗靶点。
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with a poor prognosis. Type X collagen α 1 chain (COL10A1), a member of the collagen family, is a gene associated with the progression of a variety of human tumors, but the specific function and molecular mechanism of COL10A1 in pancreatic cancer remain unclear. Our study found that COL10A1 is highly expressed in pancreatic cancer cells and tissues, and its high expression is related to poor prognosis and some clinicopathological features, such as tumor size and differentiation. Biological functional experiments showed that overexpression of COL10A1 enhanced the proliferation and migration of PDAC cells. Interestingly, discoid protein domain receptor 2 (DDR2), the receptor of COL10A1, is regulated by COL10A1. We found that the COL10A1-DDR2 axis activates the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, which leads to epithelial-mesenchymal transformation (EMT) and accelerates the progression of pancreatic cancer. In summary, COL10A1 regulates PDAC cell proliferation and MEK/ERK signaling pathways by binding to DDR2 to promote migration, invasion and EMT. Our study suggested that COL10A1 might be a critical factor in promoting PDAC progression. More research is needed to confirm COL10A1 as a potential biomarker and therapeutic target for PDAC.
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DOI：
10.1016/b978-0-12-800180-6.00002-5
发表时间：
2014
影响因子：
--
作者：
Leitinger, Birgit
通讯作者：
Leitinger, Birgit
COL10A1高表达与结直肠癌不良预后相关
影响因子：
4
作者：
Huang H;Li T;Ye G;Zhao L;Zhang Z;Mo D;Wang Y;Zhang C;Deng H;Li G;Liu H
通讯作者：
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影响因子：
17.1
作者：
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Horton WA
DOI：
10.1016/j.bbapap.2012.10.014
发表时间：
2013-10
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
28.2
作者：
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通讯作者：
Meyerson M