Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner.
Intrauterine Hyperglycemia Alters the Metabolomic Profile in Fetal Mouse Pancreas in a Gender-Specific Manner.
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宫内高血糖以性别特异性方式改变胎鼠胰腺的代谢组学特征
DOI：
10.3389/fendo.2021.710221
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发表时间：
2021
影响因子：
5.2
通讯作者：
Huang HF
中科院分区：
文献类型：
--
作者：
Zhu H;Luo SS;Cheng Y;Yan YS;Zou KX;Ding GL;Jin L;Huang HF
越来越多的证据表明，在发育的关键阶段，宫内高血糖暴露可能导致糖尿病患病率的增加。然而，对后代代谢紊乱的机制知之甚少。在本研究中，我们探讨了宫内高血糖暴露对胎儿胰腺代谢组的影响，以及其与成年后代糖耐量受损的潜在联系。在这里，使用GDM小鼠模型，我们发现来自男性和女性胎儿的胰腺的代谢组谱显示在几个重要途径中改变的代谢物，包括5-甲基胞嘧啶、α-KG、支链氨基酸和胱氨酸，它们分别与表观遗传修饰、胰岛素分泌和细胞内氧化还原状态相关。这一发现表明，宫内暴露于高血糖可能会导致胰腺代谢组的改变，这可能是GDM诱导的代际糖尿病易感性的代谢介导的机制。
Mounting evidence has shown that intrauterine hyperglycemia exposure during critical stages of development may be contributing to the increasing prevalence of diabetes. However, little is known about the mechanisms responsible for offspring metabolic disorder. In this present study, we explored intrauterine hyperglycemia exposure on fetal pancreatic metabolome, and its potential link to impaired glucose tolerance in adult offspring. Here, using a GDM mouse model, we found the metabolome profiling of pancreas from male and female fetus showing altered metabolites in several important pathways, including 5-methylcytosine, α-KG, branched-chain amino acids, and cystine, which are associated with epigenetic modification, insulin secretion, and intracellular redox status, respectively. This finding suggests that intrauterine exposure to hyperglycemia could cause altered metabolome in pancreas, which might be a metabolism-mediated mechanism for GDM-induced intergenerational diabetes predisposition.
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影响因子：
16.2
作者：
Gillman MW;Oakey H;Baghurst PA;Volkmer RE;Robinson JS;Crowther CA
通讯作者：
Crowther CA
影响因子：
5.6
作者：
O'Neill K;Alexander J;Azuma R;Xiao R;Snyder NW;Mesaros CA;Blair IA;Pinney SE
通讯作者：
Pinney SE
影响因子：
50.3
作者：
Xu W;Yang H;Liu Y;Yang Y;Wang P;Kim SH;Ito S;Yang C;Wang P;Xiao MT;Liu LX;Jiang WQ;Liu J;Zhang JY;Wang B;Frye S;Zhang Y;Xu YH;Lei QY;Guan KL;Zhao SM;Xiong Y
通讯作者：
Xiong Y
癌症中氨基酸的代谢
影响因子：
5.5
作者：
Wei Z;Liu X;Cheng C;Yu W;Yi P
通讯作者：
Yi P
影响因子：
4.3
作者：
Kawahito, Shinji;Kitahata, Hiroshi;Oshita, Shuzo
通讯作者：
Oshita, Shuzo