Gender Specific Re-organization of Resting-State Networks in Older Age.
Gender Specific Re-organization of Resting-State Networks in Older Age.
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DOI：
10.3389/fnagi.2016.00285
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发表时间：
2016
影响因子：
4.8
通讯作者：
Bagshaw AP
中科院分区：
文献类型：
--
作者：
Goldstone A;Mayhew SD;Przezdzik I;Wilson RS;Hale JR;Bagshaw AP
年龄增长通常与大脑结构和功能的变化相关。近期，关于大脑连接性的改变可能导致认知能力随年龄增长而受损这一观点已得到研究。然而，年龄和性别对静息态网络重组的相互作用尚未完全被理解。本研究旨在探究年龄和性别对网络内和网络间功能连接（FC）的影响，以及静息态网络（RSN）节点定义可能随年龄增长而改变的程度。我们获取了年轻（n = 20）和年长（n = 20）成年人的静息态功能磁共振图像，并评估了三个主要皮质网络的功能连接：默认模式网络（DMN）、背侧注意网络（DAN）和突显网络（SN）。与年轻参与者相比，年长成年人表现出默认模式网络内部功能连接降低，以及前扣带回皮质（ACC）与背侧注意网络节点之间的网络间功能连接增加。此外，这种随着年龄增长而出现的前扣带回皮质 - 背侧注意网络间功能连接的增加主要是由男性参与者驱动的。然而，进一步的分析表明，前扣带回皮质、双侧前脑岛和眶额皮质静息态网络节点的空间位置随年龄增长而改变，并且功能连接中与年龄相关的性别差异可能反映的是空间重组，而不仅仅是功能连接强度的增加或减少。年轻和年长成年人之间在静息态网络的功能连接和空间分布上的这些差异为基本大脑网络随年龄增长而重组且受性别调节提供了证据。这些结果强调了进一步研究网络内和网络间功能连接随年龄变化的必要性，同时也需要探索性别所起的调节作用。它们还强调了在不同组之间直接比较静息态网络节点功能连接的困难，并建议在使用相同的静息态网络节点定义对不同年龄或患者群体进行功能连接研究时应谨慎。
Advancing age is commonly associated with changes in both brain structure and function. Recently, the suggestion that alterations in brain connectivity may drive disruption in cognitive abilities with age has been investigated. However, the interaction between the effects of age and gender on the re-organization of resting-state networks is not fully understood. This study sought to investigate the effect of both age and gender on intra- and inter-network functional connectivity (FC) and the extent to which resting-state network (RSN) node definition may alter with older age. We obtained resting-state functional magnetic resonance images from younger (n = 20) and older (n = 20) adults and assessed the FC of three main cortical networks: default mode (DMN), dorsal attention (DAN), and saliency (SN). Older adults exhibited reduced DMN intra-network FC and increased inter-network FC between the anterior cingulate cortex (ACC) and nodes of the DAN, in comparison to younger participants. Furthermore, this increase in ACC-DAN inter-network FC with age was driven largely by male participants. However, further analyses suggested that the spatial location of ACC, bilateral anterior insula and orbitofrontal cortex RSN nodes changed with older age and that age-related gender differences in FC may reflect spatial re-organization rather than increases or decreases in FC strength alone. These differences in both the FC and spatial distribution of RSNs between younger and older adults provide evidence of re-organization of fundamental brain networks with age, which is modulated by gender. These results highlight the need to further investigate changes in both intra- and inter-network FC with age, whilst also exploring the modifying effect of gender. They also emphasize the difficulties in directly comparing the FC of RSN nodes between groups and suggest that caution should be taken when using the same RSN node definitions for different age or patient groups to investigate FC.
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DOI：
10.1037/0278-7393.34.4.791
发表时间：
2008-07
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
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Dennis NA;Hayes SM;Prince SE;Madden DJ;Huettel SA;Cabeza R
通讯作者：
Cabeza R