Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus.
Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus.
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DOI：
10.1186/1471-2474-5-37
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发表时间：
2004-10-20
影响因子：
2.3
通讯作者：
Malemud CJ
中科院分区：
文献类型：
--
作者：
Denko CW;Malemud CJ
系统性红斑狼疮是一种年龄和性别相关的自身免疫性疾病。以往的研究表明，下丘脑/垂体轴的缺陷有助于系统性红斑狼疮疾病的进展，这也可能涉及生长激素，胰岛素样生长因子-1和生长抑素的功能。本研究旨在比较女性系统性红斑狼疮患者与正常女性的基础血清生长激素、胰岛素样生长因子-1和生长抑素水平。基础血清生长激素，胰岛素样生长因子-1和生长抑素水平测定标准放射免疫法。在整个正常受试者组（即20 - 80岁）中，血清生长激素水平与年龄无关（r2 = 3.03）。相反，血清胰岛素样生长因子-1水平与年龄呈负相关（调整后的r2 = 0.092）。值得注意的是，在20 - 46岁的范围内，血清生长激素与年龄呈正相关（校正后的r2 = 0.269），这与系统性红斑狼疮组患者的年龄范围重叠。在这方面，与整个正常受试者组（20 - 80岁）或与系统性红斑狼疮患者年龄匹配的正常受试者相比，血清生长激素水平并不显著更高。系统性红斑狼疮患者血清胰岛素样生长因子-1水平显著升高（p <0.001），但仅与整个正常受试者组相比。血清生长抑素水平仅在老年（即> 55岁）系统性红斑狼疮患者中与正常人不同。这些结果表明，当将来自系统性红斑狼疮患者的血清样品与年龄匹配的正常女性受试者进行比较时，系统性红斑狼疮的特征不在于生长激素/胰岛素样生长因子-1旁分泌轴的调节。这些结果在系统性红斑狼疮不同于以前报道的其他肌肉骨骼疾病，如类风湿性关节炎，骨关节炎，纤维肌痛，弥漫性特发性骨肥厚和高活动综合征，其中显着较高的血清生长激素levels.Somatostatin水平在老年系统性红斑狼疮患者可能提供了一个临床标志物的疾病活动在这些患者。
Systemic lupus erythematosus is an age- and gender-associated autoimmune disorder. Previous studies suggested that defects in the hypothalamic/pituitary axis contributed to systemic lupus erythematosus disease progression which could also involve growth hormone, insulin-like growth factor-1 and somatostatin function. This study was designed to compare basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels in female systemic lupus erythematosus patients to a group of normal female subjects. Basal serum growth hormone, insulin-like growth factor-1 and somatostatin levels were measured by standard radioimmunoassay. Serum growth hormone levels failed to correlate with age (r2 = 3.03) in the entire group of normal subjects (i.e. 20 – 80 years). In contrast, serum insulin-like growth factor-1 levels were inversely correlated with age (adjusted r2 = 0.092). Of note, serum growth hormone was positively correlated with age (adjusted r2 = 0.269) in the 20 – 46 year range which overlapped with the age range of patients in the systemic lupus erythematosus group. In that regard, serum growth hormone levels were not significantly higher compared to either the entire group of normal subjects (20 – 80 yrs) or to normal subjects age-matched to the systemic lupus erythematosus patients. Serum insulin-like growth factor-1 levels were significantly elevated (p < 0.001) in systemic lupus erythematosus patients, but only when compared to the entire group of normal subjects. Serum somatostatin levels differed from normal subjects only in older (i.e. >55 yrs) systemic lupus erythematosus patients. These results indicated that systemic lupus erythematosus was not characterized by a modulation of the growth hormone/insulin-like growth factor-1 paracrine axis when serum samples from systemic lupus erythematosus patients were compared to age- matched normal female subjects. These results in systemic lupus erythematosus differ from those previously reported in other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, fibromyalgia, diffuse idiopathic skeletal hyperostosis and hypermobility syndrome where significantly higher serum growth hormone levels were found. Somatostatin levels in elderly systemic lupus erythematosus patients may provide a clinical marker of disease activity in these patients.
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影响因子：
--
作者：
HOCHBERG, MC;LETHBRIDGECEJKU, M;TOBIN, JD
通讯作者：
TOBIN, JD
影响因子：
2.6
作者：
Bae, YS;Bae, SC;Kim, SY
通讯作者：
Kim, SY
影响因子：
2.3
作者：
Chikanza, IC;Kuis, W;Heijnen, CJ
通讯作者：
Heijnen, CJ
影响因子：
4
作者：
Denko, CW;Boja, B;Malemud, CJ
通讯作者：
Malemud, CJ
DOI：
10.1111/j.1749-6632.1999.tb07623.x
发表时间：
1999-01-01
期刊：
NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES
影响因子：
--
作者：
Lahita, RG
通讯作者：
Lahita, RG