Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology.
Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology.
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DOI：
10.1177/15333175221082834
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发表时间：
2022-01
影响因子：
3.4
通讯作者：
Li, Chiang-Shan R.
中科院分区：
文献类型：
--
作者：
Chaudhary, Shefali;Zhornitsky, Simon;Chao, Herta H.;van Dyck, Christopher H.;Li, Chiang-Shan R.
我们描述了行为研究来强调阿尔茨海默病 (AD) 中的情绪处理缺陷。研究结果表明，AD 患者在识别负面情绪方面存在显着缺陷，积极情绪对增强记忆力有显着影响，而认知缺陷在表现情绪处理功能障碍方面发挥着关键作用。我们回顾了影像学研究，以强调情绪处理缺陷中海马回路功能障碍的形态和功能标记。尽管杏仁核对情绪刺激有反应，但海马功能障碍会导致情绪记忆缺陷。最后，回顾性研究表明主要神经递质系统与 AD 焦虑和抑郁有关，支持 AD 情绪障碍中胆碱能和去甲肾上腺素能信号的改变。总体而言，这些研究显示在病程早期情绪发生了变化，并表明需要多模态成像进行进一步研究。特别是，在临床前和临床模型之间可转换的多种行为范式的纵向研究将提供数据来阐明 AD 情绪处理功能障碍的时间过程和潜在的神经生物学。
We described behavioral studies to highlight emotional processing deficits in Alzheimer’s disease (AD). The findings suggest prominent deficit in recognizing negative emotions, pronounced effect of positive emotion on enhancing memory, and a critical role of cognitive deficits in manifesting emotional processing dysfunction in AD. We reviewed imaging studies to highlight morphometric and functional markers of hippocampal circuit dysfunction in emotional processing deficits. Despite amygdala reactivity to emotional stimuli, hippocampal dysfunction conduces to deficits in emotional memory. Finally, the reviewed studies implicating major neurotransmitter systems in anxiety and depression in AD supported altered cholinergic and noradrenergic signaling in AD emotional disorders. Overall, the studies showed altered emotions early in the course of illness and suggest the need of multimodal imaging for further investigations. Particularly, longitudinal studies with multiple behavioral paradigms translatable between preclinical and clinical models would provide data to elucidate the time course and underlying neurobiology of emotion processing dysfunction in AD.
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影响因子：
5.7
作者：
Badgaiyan, Rajendra D.;Fischman, Alan J.;Alpert, Nathaniel M.
通讯作者：
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影响因子：
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作者：
Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1710819114
发表时间：
2017-08-22
影响因子：
11.1
作者：
Atucha, Erika;Vukojevic, Vanja;Roozendaal, Benno
通讯作者：
Roozendaal, Benno