Measurement of circulation time in the retinal vasculature using selective angiography.
Measurement of circulation time in the retinal vasculature using selective angiography.
复制标题
使用选择性血管造影测量视网膜脉管系统的循环时间。
DOI：
10.1016/s0161-6420(90)32463-6
复制
发表时间：
1990
期刊：
影响因子：
13.7
通讯作者：
Peyman,GA
中科院分区：
文献类型：
--
作者：
Khoobehi,B;Schuele,KM;Ali,OM;Peyman,GA
视网膜血管系统中的视网膜循环时间（RCT）和平均循环时间（MCT）已用于确定眼部疾病对视网膜循环的影响。RCT和MCT通常通过在传统荧光素血管造影期间测量染料稀释曲线来确定。作者提出了一种染料稀释技术的变体。主要区别在于荧光染料（羧基荧光素或钙黄绿素）以非常高的浓度包封在脂质体中。然后，通过眼睛瞳孔传递的激光脉冲将染料释放到视网膜动脉的特定部位。激光产生的热脉冲裂解靶血管中的脂质体，导致染料流释放。然后测量染料前沿通过动脉并通过静脉返回所需的时间（RCT）。为了澄清这种情况，实际测量了两次，即染料从暴露部位到静脉上相应部位的最短路径（短RCT）和通过外周到静脉充盈的最长路径（长RCT）。在食蟹猴和松鼠猴中进行测量。发现用这种方法实现的局部染料释放产生比传统血管造影术更明显的染料前沿，同时还消除了再循环的问题。脉络膜背景荧光，一个因素，往往掩盖了传统的血管造影染料前沿，是最小的。此外，可以对四条动脉中的每一条进行单独测量，并重复测量几次。
Retinal circulation times (RCT) and mean circulation time (MCT) in the retinal vasculature have been used to determine the effect of ocular disease on retinal circulation. Both RCT and MCT are usually determined by measuring dye dilution curves during a traditional fluorescein angiogram. The authors present a variation of the dye dilution technique. The primary difference is that a fluorescent dye (carboxyfluorescein or calcein) was encapsulated in liposomes at a very high concentration. The dye was then released at a specific site in a retinal artery by the application of a laser pulse delivered through the pupil of the eye. The heat pulse produced by the laser lysed the liposomes in the targeted vessel, causing a stream of dye to be released. The time it took the dye front to pass through the artery and return through the vein (RCT) was then measured. To clarify the situation, two times were actually measured, the shortest path the dye traveled from the exposure site to a corresponding site on the vein (short RCT) and the longest path through the periphery to venous filling (long RCT). The measurements were made in both cynomolgus monkeys and squirrel monkeys. The local dye release achieved with this method was found to produce a more distinct dye front than traditional angiography while also eliminating the problem of recirculation. Choroidal background fluorescence, a factor that often obscures the dye front in traditional angiography, was minimal. Furthermore, it was possible to make individual measurements on each of the four arteries and to repeat the measurements several times.
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视网膜循环的相对光度测量（荧光图）：一种电视技术
影响因子：
--
作者：
S. Fonda;B. Bagolini
通讯作者：
B. Bagolini
通过蓝光内视技术测量糖尿病视网膜病变中视网膜血流的自动调节。
影响因子：
13.7
作者：
T. Fallon;D. Maxwell;E. Kohner
通讯作者：
E. Kohner
对视网膜单个血管进行重复、选择性血管造影。
DOI：
10.1097/00006982-198909020-00003
发表时间：
1989
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Khoobehi,B;Niesman,MR;Peyman,GA;Oncel,M
通讯作者：
Oncel,M
脂质体。
影响因子：
3
作者：
M. Ostro
通讯作者：
M. Ostro
影响因子：
--
作者：
J. Cunha;J. Lima
通讯作者：
J. Lima