Effects of diets supplemented with branched-chain amino acids on the performance and fatigue mechanisms of rats submitted to prolonged physical exercise.
Effects of diets supplemented with branched-chain amino acids on the performance and fatigue mechanisms of rats submitted to prolonged physical exercise.
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DOI：
10.3390/nu4111767
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发表时间：
2012-11-16
期刊：
影响因子：
5.9
通讯作者：
Tirapegui J
中科院分区：
文献类型：
--
作者：
Falavigna G;Alves de Araújo J Jr;Rogero MM;Pires IS;Pedrosa RG;Martins E Jr;Alves de Castro I;Tirapegui J
本研究旨在确定长期补充支链氨基酸(BCAA)的饮食对训练大鼠疲劳机制的影响。对36只成年Wistar大鼠进行为期6周的训练。训练方案包括游泳锻炼(每天一小时，每周五次，为期六周)。对照组(C)12只，饲料中添加3.57%支链氨基酸(S1)12只，添加4.76%支链氨基酸(S2)12只。在训练方案的最后一天，每组动物在游泳1小时(1H)后处死一半，另一半在游泳力竭试验(EX)后处死。与C组相比，S1组游泳至力竭的时间增加了37%，S2组减少了43%。结果表明，S1组通过节省比目鱼肌中的糖原(p<；0.05)并通过降低血氨浓度而对性能产生有利影响，而S2组由于高氨血症而对性能产生负面影响(p<；0.05)。下丘脑5-羟色胺浓度在1H和EX条件下无显著差异。总而言之，长期补充支链氨基酸可提高游泳试验大鼠的运动能力，使其精疲力竭。然而，这是一种剂量依赖的效应，因为长期摄入过量的支链氨基酸会导致性能下降。
This study aimed to determine the effects of diets chronically supplemented with branched-chain amino acids (BCAA) on the fatigue mechanisms of trained rats. Thirty-six adult Wistar rats were trained for six weeks. The training protocol consisted of bouts of swimming exercise (one hour a day, five times a week, for six weeks). The animals received a control diet (C) (n = 12), a diet supplemented with 3.57% BCAA (S1) (n = 12), or a diet supplemented with 4.76% BCAA (S2) (n = 12). On the last day of the training protocol, half the animals in each group were sacrificed after one hour of swimming (1H), and the other half after a swimming exhaustion test (EX). Swimming time until exhaustion was increased by 37% in group S1 and reduced by 43% in group S2 compared to group C. Results indicate that the S1 diet had a beneficial effect on performance by sparing glycogen in the soleus muscle (p < 0.05) and by inducing a lower concentration of plasma ammonia, whereas the S2 diet had a negative effect on performance due to hyperammonemia (p < 0.05). The hypothalamic concentration of serotonin was not significantly different between the 1H and EX conditions. In conclusion, chronic BCAA supplementation led to increased performance in rats subjected to a swimming test to exhaustion. However, this is a dose-dependent effect, since chronic ingestion of elevated quantities of BCAA led to a reduction in performance.
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DOI：
10.1139/h02-005
发表时间：
2002-02-01
期刊：
CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE
影响因子：
--
作者：
McCully, KK;Authier, B;Clark, BJ
通讯作者：
Clark, BJ
影响因子：
7
作者：
Jakeman, PM
通讯作者：
Jakeman, PM
影响因子：
3.4
作者：
Meeusen, Romain;Watson, Philip;Piacentini, Maria F.
通讯作者：
Piacentini, Maria F.
DOI：
10.1097/00005768-199709000-00010
发表时间：
1997-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Calders, P;Pannier, JL;Lacroix, EM
通讯作者：
Lacroix, EM
影响因子：
7.1
作者：
Davis, JM;Alderson, NL;Welsh, RS
通讯作者：
Welsh, RS