Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016.
Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016.
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DOI：
10.1038/s41426-017-0011-z
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发表时间：
2018-01-24
影响因子：
13.2
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Wang J;Teng Z;Cui X;Li C;Pan H;Zheng Y;Mao S;Yang Y;Wu L;Guo X;Zhang X;Zhu Y
除了肠道病毒71（EV 71）和科萨基病毒A16（CV-A16），已知引起手足口病（HFMD）的病毒外，其他引起HFMD的肠道病毒的流行病学特征有限。我们收集了2012-2016年上海市9949例手足口病实验室监测病例和1230份婴儿和儿童血清样本。自2013年以来，CV-A6已取代EV 71和CV-A16成为主要血清型。有趣的是，在EV 71和CV-A16感染中观察到了新的流行病学模式，在2012年和2014年都有一个大的高峰，随后在随后的几年（2013年和2015年）分别有两个较小的高峰。测序结果表明，C4 a、B1 B、D-Cluster-1和B分别为EV 71、CV-A16、CV-A6和CV-A10的主要亚型。在健康人群中，50.49%和54.23%的人分别对EV 71和CV-A16中和抗体（NtAbs）阳性，表明EV 71和CV-A16沉默感染是常见的。这些人群可能是重要的潜在感染源。EV 71 NtAb的总体血清阳性率呈波动性、显著下降趋势，表明未来EV 71流行的潜在风险。高CV-A16 NtAb血清阳性率证实了记录的CV-A16“沉默”流行。1-5岁儿童的EV 71 NtAb血清阳性率最低，而1-2岁儿童的CV-A16 NtAb血清阳性率最低。这是2012年至2016年上海手足口病流行病学和病原学以及血清阳性率的首次全面调查。这项研究为开发更有效的HMFD疫苗接种计划提供了最新见解。
Aside from enterovirus 71 (EV71) and coxsackie virus A16 (CV-A16), viruses that are known to cause hand-foot-and-mouth disease (HFMD), epidemiological profiles of other enteroviruses that induce HFMD are limited. We collected 9949 laboratory surveillance HFMD cases and 1230 serum samples from infants and children in Shanghai from 2012–2016. Since 2013, CV-A6 has displaced EV71 and CV-A16 to become the predominant serotype. Interestingly, novel epidemiological patterns in EV71 and CV-A16 infections were observed, with one large peak in both 2012 and 2014, followed by two smaller peaks in the respective following years (2013 and 2015). Through sequencing, we found that C4a, B1b, D-Cluster-1 and B constituted the major subgenotypes of EV71, CV-A16, CV-A6 and CV-A10, respectively. Among healthy individuals, 50.49% and 54.23% had positive neutralising antibodies (NtAbs) against EV71 and CV-A16, respectively, indicating that EV71 and CV-A16 silent infections were common. These populations may be an important potential source of infection. The overall seropositive rate of EV71 NtAbs showed a fluctuating, markedly downward trend, indicating the potential risk of a future EV71 epidemic. High CV-A16 NtAb seroprevalence corroborated a documented CV-A16 ‘silent’ epidemic. Children aged 1–5 years had the lowest EV71 NtAb seropositive rate, whereas those aged 1–2 years exhibited the lowest CV-A16 NtAb seropositive rate. This is the first comprehensive investigation of the epidemiology and aetiology, as well as the seroprevalence, of HFMD in Shanghai between 2012 and 2016. This study provides the latest insights into developing a more efficient HMFD vaccination programme.
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影响因子：
8
作者：
Chen, Kow-Tong;Chang, Hsiao-Ling;Yang, Jyh-Yuan
通讯作者：
Yang, Jyh-Yuan
影响因子：
4.6
作者：
Feng X;Guan W;Guo Y;Yu H;Zhang X;Cheng R;Wang Z;Zhang Z;Zhang J;Li H;Zhuang Y;Zhang H;Lu Z;Li M;Yu H;Bao Y;Hu Y;Yao Z
通讯作者：
Yao Z
影响因子：
8.8
作者：
Blomqvist, Soile;Klemola, Paivi;Roivainen, Merja
通讯作者：
Roivainen, Merja
影响因子：
3.6
作者：
Hu, Ya-Qian;Xie, Guang-Cheng;Duan, Zhao-Jun
通讯作者：
Duan, Zhao-Jun
影响因子：
4.2
作者：
He, S. Z.;Chen, M. Y.;Xia, N. S.
通讯作者：
Xia, N. S.