Time-Restricted Eating in Metabolic Syndrome-Focus on Blood Pressure Outcomes.
Time-Restricted Eating in Metabolic Syndrome-Focus on Blood Pressure Outcomes.
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DOI：
10.1007/s11906-022-01219-z
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发表时间：
2022-11
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
时间限制饮食（TRE）是一种很有前途的减肥和改善心脏代谢危险因素的饮食干预。我们的目标是提供一个严格的审查血压结果报告的临床TRE研究中的成年人代谢综合征，在提出的机制的背景下，进食时间和血压之间的关系。临床TRE研究报告了与血压结局相关的混合结果，可能是由于研究设计和TRE方案的显著异质性。从机制上讲，TRE的代谢益处被推测为通过将进餐时间与代谢过程的昼夜节律调节和/或由于延长禁食期而增强的catastrophic对齐来介导。开始和结束较早的TRE方案似乎具有更明显的降血压效果。血压也往往是较低的狭窄的饮食窗口。同时减肥并不总是与血压降低有关，而较低的胰岛素水平可能是血压降低的一个重要因素。值得注意的是，没有发表的研究报告24小时血压曲线或血压变异性的数据。仅在有限的TRE研究中检查了血压，在单个时间点测量。考虑到血压昼夜变化的临床相关性以及进食时间和血压影响的机制证据，需要更多的研究来调查TRE对血压昼夜变化的影响。
Time-restricted eating (TRE) is a promising dietary intervention for weight loss and improvement of cardiometabolic risk factors. We aim to provide a critical review of blood pressure outcomes reported in clinical TRE studies in adults with metabolic syndrome, in the context of the proposed mechanisms that underlie the relationship between timing of eating and blood pressure. Clinical TRE studies report mixed results pertaining to blood pressure outcomes, likely due to significant heterogeneity in study design and TRE protocols. Mechanistically, TRE’s metabolic benefits have been speculated to be mediated by alignment of meal timing with circadian regulation of metabolic processes and/or enhancement of catabolism as a result of prolonging the fasting period. TRE protocols that start and end earlier appear to have more pronounced blood pressure lowering effects. Blood pressure also tends to be lower with narrower eating windows. Concurrent weight loss is not consistently linked to blood pressure reduction, while lower insulin levels may be an important factor for blood pressure reduction. Notably, no published studies have reported 24-h blood pressure profiles or data on blood pressure variability. Blood pressure has only been examined in limited TRE studies, measured at a single time point. Given the clinical relevance of blood pressure’s diurnal variability and the mechanistic evidence underlying timing of eating and blood pressure effects, more studies are needed to investigate TRE’s effects on the diurnal variability of blood pressure.
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影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
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Mashek, Douglas G.
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8.3
作者：
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通讯作者：
VANCAUTER, E
影响因子：
15.9
作者：
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通讯作者：
DAVIS, PJ