Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex.
Distinct Translaminar Glutamatergic Circuits to GABAergic Interneurons in the Neonatal Auditory Cortex.
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DOI：
10.1016/j.celrep.2017.04.044
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发表时间：
2017-05-09
期刊：
影响因子：
8.8
通讯作者：
Kanold PO
中科院分区：
文献类型：
--
作者：
Deng R;Kao JPY;Kanold PO
GABA能活性在新皮层发育和可塑性中是重要的。由于GABA能中间神经元的成熟受到神经活动的调节，因此GABA能中间神经元的兴奋性输入来源在发育中起着关键作用。我们通过激光扫描光刺激显示，新生小鼠（< P7）听觉皮层中的第4层和第5层GABA能中间神经元通过仅NMDAR的突触接受广泛的跨层GABA能输入。广泛的translaminar AMPAR介导的输入在出生后第二周，而NMDAR的突触前连接减少。GABA能中间神经元表现出两种空间模式的translaminar连接：输入主要来自颗粒上或颗粒上和颗粒下层，包括subplate中继早期丘脑皮质活动。感觉剥夺改变了经椎板输入的发展。因此，在整个发育过程中，GABA能中间神经元存在不同的跨层回路，兴奋性突触的成熟是输入特异性的。来自基板和皮质内来源的谷氨酸能信号可能在GABA能中间神经元的成熟中起作用。
GABAergic activity is important in neocortical development and plasticity. Since the maturation of GABAergic interneurons is regulated by neural activity, the source of excitatory inputs to GABAergic interneurons plays a key role in development. We show by laser-scanning photostimulation that layer 4 and layer 5 GABAergic interneurons in auditory cortex in neonatal mice (< P7) receive extensive translaminar glutamatergic input via NMDAR-only synapses. Extensive translaminar AMPAR-mediated input developed during the second postnatal week while NMDAR-only presynaptic connections decreased. GABAergic interneurons showed two spatial patterns of translaminar connection: inputs originating predominantly from supragranular or from supragranular and infragranular layers including subplate which relays early thalamocortical activity. Sensory deprivation altered the development of translaminar inputs. Thus, distinct translaminar circuits to GABAergic interneurons exist throughout development and the maturation of excitatory synapses is input specific. Glutamatergic signaling from subplate and intracortical sources likely plays a role in the maturation of GABAergic interneurons.
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影响因子：
25
作者：
De Marco García NV;Priya R;Tuncdemir SN;Fishell G;Karayannis T
通讯作者：
Karayannis T
影响因子：
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Meng, Xiangying;Kao, Joseph P. Y.;Kanold, Patrick O.
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Fishell, Gord
影响因子：
64.8
作者：
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通讯作者：
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