Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.
Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism.
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DOI：
10.1159/000337310
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发表时间：
2012
影响因子：
3.9
通讯作者：
Zeisel SH
中科院分区：
文献类型：
--
作者：
Zeisel SH
代谢个体的潜在机制之一是遗传变异。代谢途径基因中的单核苷酸多态性（SNPs）会导致代谢效率低下，从而改变对营养物质的饮食需求和反应。这些SNPS可以通过基因图谱检测到，它们引起的代谢效率低下可以通过代谢组学图谱检测到。对人类饮食中胆碱需求的研究说明了这些新方法是多么有用，因为这种需求受到胆碱和叶酸代谢基因snp的影响。在成年人中，这些snp决定了人们在吃低胆碱饮食时是否会患上脂肪肝、肝损伤和肌肉损伤。因为胆碱对胎儿发育非常重要，这些snp可以确定在怀孕期间需要摄入更多胆碱的女性。胆碱的一些作用是由表观遗传机制介导的，这种机制允许在生命早期代谢途径的“回归”。
One of the underlying mechanisms for metabolic individuality is genetic variation. Single nucleotide polymorphisms (SNPs) in genes of metabolic pathways can create metabolic inefficiencies that alter the dietary requirement for, and responses to nutrients. These SNPS can be detected using genetic profiling and the metabolic inefficiencies they cause can be detected using metabolomic profiling. Studies on the human dietary requirement for choline illustrate how useful these new approaches can be, as this requirement is influenced by SNPs in genes of choline and folate metabolism. In adults, these SNPs determine whether people develop fatty liver, liver damage and muscle damage when eating diets low in choline. Because choline is very important for fetal development, these SNPs may identify women who need to eat more choline during pregnancy. Some of the actions of choline are mediated by epigenetic mechanisms that permit “retuning” of metabolic pathways during early life.
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影响因子：
4.8
作者：
da Costa, Kerry-Ann;Kozyreva, Olga G.;Zeisel, Steven H.
通讯作者：
Zeisel, Steven H.
DOI：
10.1016/j.devbrainres.2005.07.002
发表时间：
2005-10-06
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Albright, CD;Mar, MH;Zeisel, SH
通讯作者：
Zeisel, SH
影响因子：
2.2
作者：
MECK, WH;SMITH, RA;WILLIAMS, CL
通讯作者：
WILLIAMS, CL
影响因子：
4.2
作者：
Bailey, LB;Gregory, JF
通讯作者：
Gregory, JF
影响因子：
3.5
作者：
Meck, Warren H;Williams, Christina L;Cermak, Jennifer Marie;Blusztajn, Jan Krzysztof
通讯作者：
Blusztajn, Jan Krzysztof