Value-based modulation of memory encoding involves strategic engagement of fronto-temporal semantic processing regions.
Value-based modulation of memory encoding involves strategic engagement of fronto-temporal semantic processing regions.
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DOI：
10.3758/s13415-014-0275-x
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Knowlton BJ
中科院分区：
文献类型：
--
作者：
Cohen MS;Rissman J;Suthana NA;Castel AD;Knowlton BJ
许多先前的fMRI研究集中在中脑多巴胺能奖励系统与海马体共同激活的方式上，以增强对有价值物品的记忆。然而，人们可以选择性地记住更有价值的东西的另一种方法是选择性地使用有效但费力的编码策略。为了更广泛地研究价值对后续记忆的神经机制，我们使用功能磁共振成像（fMRI）来研究大脑编码活动作为价值函数的差异如何与随后的单词自由回忆相关。每个单词之前都有一个随机分配的分值，参与者经历了多个研究测试周期，并在每个列表的末尾反馈他们的总分，从而形成认知策略。我们研究了大脑活动的价值相关调节与参与者的选择性指数之间的相关性，选择性指数是一种衡量参与者在给定回忆的项目数量的情况下与他们的最佳积分有多接近的指标。在编码高价值词汇时，相对于编码低价值词汇，高选择性得分与语义加工区域（包括左额下回和左后外侧颞叶皮层）的激活差异更大相关。虽然我们也在中脑和腹侧纹状体奖赏区观察到与价值相关的调节，但我们的额颞叶研究结果表明，深度语义处理的战略性参与可能是选择性编码有价值物品的重要机制。
A number of prior fMRI studies have focused on the ways in which the midbrain dopaminergic reward system co-activates with hippocampus to potentiate memory for valuable items. However, another means by which people could selectively remember more valuable to-be-remembered items is to be selective in their use of effective but effortful encoding strategies. To broadly examine the neural mechanisms of value on subsequent memory, we used fMRI to examine how differences in brain activity at encoding as a function of value relate to subsequent free recall for words. Each word was preceded by an arbitrarily assigned point value, and participants went through multiple study-test cycles with feedback on their point total at the end of each list, allowing for sculpting of cognitive strategies. We examined the correlation between value-related modulation of brain activity and participants’ selectivity index, a measure of how close participants were to their optimal point total given the number of items recalled. Greater selectivity scores were associated with greater differences in activation of semantic processing regions, including left inferior frontal gyrus and left posterior lateral temporal cortex, during encoding of high-value words relative to low-value words. Although we also observed value-related modulation within midbrain and ventral striatal reward regions, our fronto-temporal findings suggest that strategic engagement of deep semantic processing may be an important mechanism for selectively encoding valuable items.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
4
作者：
Castel, Alan D.;Humphreys, Kathryn L.;McCabe, David P.
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McCabe, David P.
DOI：
10.1073/pnas.91.6.2008
发表时间：
1994-03-15
影响因子：
11.1
作者：
KAPUR, S;CRAIK, FIM;BROWN, GM
通讯作者：
BROWN, GM
影响因子：
5.7
作者：
Kim, Hongkeun
通讯作者：
Kim, Hongkeun
DOI：
10.1073/pnas.92.7.2446
发表时间：
1995-03-28
影响因子：
11.1
作者：
HUANG, YY;KANDEL, ER
通讯作者：
KANDEL, ER