Optically enhanced acoustophoresis
Optically enhanced acoustophoresis
复制标题
光学增强声泳
DOI：
10.1117/12.2276323
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Demore C
中科院分区：
文献类型：
--
作者：
Demore C
再生医学有能力彻底改变医疗保健的许多方面，但要从小规模的自体治疗向大规模的同种异体治疗迈出一步，需要强大且可扩展的无标签细胞分选技术作为细胞治疗生物处理管道的一部分。在这篇论文中，我们描述了几种不需要标记就能满足高通量要求的策略：维度缩放、稀有物种定位和从稳定状态分类。这三种方法通过光学和超声力的结合来证明。通过结合来自两种不同模式的大多数保守力和非保守力，可以减少流速对分选效率的影响，从而提高鲁棒性和可扩展性。一种这样的方法可以被称为“光学增强声电泳”，它结合了声学处理大量分析物的能力和光学分选的高特异性。
Regenerative medicine has the capability to revolutionise many aspects of medical care, but for it to make the step from small scale autologous treatments to larger scale allogeneic approaches, robust and scalable label free cell sorting technologies are needed as part of a cell therapy bioprocessing pipeline. In this proceedings we describe several strategies for addressing the requirements for high throughput without labeling via: dimensional scaling, rare species targeting and sorting from a stable state. These three approaches are demonstrated through a combination of optical and ultrasonic forces. By combining mostly conservative and non-conservative forces from two different modalities it is possible to reduce the influence of flow velocity on sorting efficiency, hence increasing robustness and scalability. One such approach can be termed "optically enhanced acoustophoresis" which combines the ability of acoustics to handle large volumes of analyte with the high specificity of optical sorting.
偏振光片断层扫描。
影响因子：
3.8
作者：
Sascha Reidt;Daniel J. O'Brien;K. Wood;M. MacDonald
通讯作者：
M. MacDonald
影响因子：
6.1
作者：
Shields CW 4th;Reyes CD;López GP
通讯作者：
López GP
影响因子：
7.4
作者：
Kaneta, T;Ishidzu, Y;Imasaka, T
通讯作者：
Imasaka, T