Music and methamphetamine: conditioned cue-induced increases in locomotor activity and dopamine release in rats.
Music and methamphetamine: conditioned cue-induced increases in locomotor activity and dopamine release in rats.
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DOI：
10.1016/j.pbb.2010.11.024
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发表时间：
2011-03
影响因子：
3.6
通讯作者：
Glick, S. D.
中科院分区：
文献类型：
--
作者：
Polston, J. E.;Rubbinaccio, H. Y.;Morra, J. T.;Sell, E. M.;Glick, S. D.
药物滥用与线索之间的联系促进了成瘾行为的获得和维持。尽管已经做了大量的研究来阐明简单的判别性或离散条件刺激（例如，音调或光线）在成瘾中的作用，但对复杂的环境线索知之甚少。本研究的目的是通过评估运动活动和体内微透析来检查音乐条件刺激的作用。两组大鼠随机注射甲基苯丙胺（1.0 mg/kg）或对照物，置于标准调节室。在这些条件反射过程中，两组人都暴露在连续的条件刺激下，以音乐选择（迈尔斯·戴维斯的“四”）的形式反复播放90分钟。在连续7天条件反射后，受试者休息一天，随后在没有药物的情况下测试运动活动或多巴胺释放，同时持续存在音乐条件刺激。检查的大脑区域包括基底外侧杏仁核、伏隔核和前额皮质。结果表明，音乐是一种有效的情境条件刺激，在反复接触甲基苯丙胺后显著增加运动活动。此外，这种音乐条件刺激显著增加了基底外侧杏仁核和伏隔核的细胞外多巴胺水平。这些发现支持了其他证据，表明这些大脑区域在条件学习范式中的重要性，并表明音乐是一种有效的条件刺激，值得进一步研究。
Associations between drugs of abuse and cues facilitate the acquisition and maintenance of addictive behaviors. Although significant research has been done to elucidate the role that simple discriminative or discrete conditioned stimuli (e.g., a tone or a light) play in addiction, less is known about complex environmental cues. The purpose of the present study was to examine the role of a musical conditioned stimulus by assessing locomotor activity and in vivo microdialysis. Two groups of rats were given non-contingent injections of methamphetamine (1.0 mg/kg) or vehicle and placed in standard conditioning chambers. During these conditioning sessions both groups were exposed to a continuous conditioned stimulus, in the form of a musical selection (“Four” by Miles Davis) played repeatedly for ninety minutes. After seven consecutive conditioning days subjects were given one day of rest, and subsequently tested for locomotor activity or dopamine release in the absence of drug while the musical conditioned stimulus was continually present. The brain regions examined included the basolateral amygdala, nucleus accumbens, and prefrontal cortex. The results show that music is an effective contextual conditioned stimulus, significantly increasing locomotor activity after repeated association with methamphetamine. Furthermore, this musical conditioned stimulus significantly increased extracellular dopamine levels in the basolateral amygdala and nucleus accumbens. These findings support other evidence showing the importance of these brain regions in conditioned learning paradigms, and demonstrate that music is an effective conditioned stimulus warranting further investigation.
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影响因子：
2.7
作者：
Feltenstein, Matthew W.;See, Ronald E.
通讯作者：
See, Ronald E.
影响因子：
25
作者：
Ito, R;Robbins, TW;Everitt, BJ
通讯作者：
Everitt, BJ
影响因子：
2
作者：
LaLumiere, RT;Nawar, EM;McGaugh, JL
通讯作者：
McGaugh, JL
DOI：
10.1073/pnas.191355898
发表时间：
2001-09-25
影响因子：
11.1
作者：
Blood, AJ;Zatorre, RJ
通讯作者：
Zatorre, RJ
影响因子：
3.4
作者：
Di Pietro, Nina C.;Black, Yolanda D.;Kantak, Kathleen M.
通讯作者：
Kantak, Kathleen M.