Calcium Phosphate Delivery Systems for Regeneration and Biomineralization of Mineralized Tissues of the Craniofacial Complex.
Calcium Phosphate Delivery Systems for Regeneration and Biomineralization of Mineralized Tissues of the Craniofacial Complex.
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DOI：
10.1021/acs.molpharmaceut.2c00652
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发表时间：
2023-02-06
影响因子：
4.9
通讯作者：
Desai, Tejal A.
中科院分区：
文献类型：
--
作者：
Cuylear, Darnell L.;Elghazali, Nafisa A.;Kapila, Sunil D.;Desai, Tejal A.
关键词：
基于磷酸钙（CaP）的材料已被广泛用于颅面复合体中的矿化组织。由于它们优异的生物相容性、生物降解性和固有的骨传导性质，它们用作药物和生物活性因子的递送系统具有若干优点。在颅面复合体中的三种矿化组织（骨、牙本质和牙釉质）中，只有骨和牙本质具有某些再生特性，这些再生特性会因疾病和严重损伤而减少。因此，用携带相关药物、形态发生因子和离子的CaP递送系统靶向这些再生组织对于改善矿化组织工程领域中的组织健康至关重要。在这篇综述中，使用钙磷为基础的微粒，纳米粒子，和聚合物诱导的液体前体（PILP）无定形钙磷nanodrops用于交付颅面骨和牙本质进行了讨论。还描述了使用这些不同的形状因子来获得宏观尺度的高局部浓度的货物和/或将货物精确地递送到纳米级结构。最后，在现场使用这些CaP材料和未来的步骤交付到颅面复合体的前景。
Calcium phosphate (CaP)-based materials have been extensively used for mineralized tissues in the craniofacial complex. Owing to their excellent biocompatibility, biodegradability, and inherent osteoconductive nature, their use as delivery systems for drugs and bioactive factors has several advantages. Of the three mineralized tissues in the craniofacial complex (bone, dentin, and enamel), only bone and dentin have some regenerative properties that can diminish due to disease and severe injuries. Therefore, targeting these regenerative tissues with CaP delivery systems carrying relevant drugs, morphogenic factors, and ions is imperative to improve tissue health in the mineralized tissue engineering field. In this review, the use of CaP-based microparticles, nanoparticles, and polymer-induced liquid precursor (PILPs) amorphous CaP nanodroplets for delivery to craniofacial bone and dentin are discussed. The use of these various form factors to obtain either a high local concentration of cargo at the macroscale and/or to deliver cargos precisely to nanoscale structures is also described. Finally, perspectives on the field using these CaP materials and next steps for the future delivery to the craniofacial complex are presented.
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