Family-focused therapy for individuals at high clinical risk for psychosis: A confirmatory efficacy trial.
Family-focused therapy for individuals at high clinical risk for psychosis: A confirmatory efficacy trial.
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DOI：
10.1111/eip.13208
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发表时间：
2022-06
影响因子：
2
通讯作者：
Bearden CE
中科院分区：
文献类型：
--
作者：
Miklowitz DJ;Addington JM;O'Brien MP;Denenny DM;Weintraub MJ;Zinberg JL;Mathalon DH;Cornblatt BA;Friedman-Yakoobian MS;Stone WS;Cadenhead KS;Woods SW;Sugar CA;Cannon TD;Bearden CE
患有减轻精神病症状（APS）、短暂间歇性精神病和/或遗传风险和功能恶化的年轻人患精神病的风险很高。在之前的一项试验中，针对临床高危青少年的以家庭为中心的治疗 (FFT-CHR) 在降低 6 个月内 APS 严重程度方面比简短的心理教育更有效。这项 7 点试验将比较 FFT-CHR 与心理教育和支持干预（强化护理）对 CHR 个体在 18 个月内的 APS 和社会功能的功效。患有 CHR 综合征的参与者（N = 220，年龄 13-25 岁）将被随机分配至 FFT-CHR（18 次 1 小时的家庭心理教育课程和沟通/解决问题技能培训）或强化护理（3 次 1 小时的家庭心理教育课程，然后是 5 次个人支持课程），均持续 6 个月以上。参与者将使用移动增强的在线平台评估他们在治疗期间每周的进展。家庭沟通将在基线和治疗后通过实验室互动任务进行评估。独立评估员将在 18 个月内每 6 个月评估 APS（主要结果）和心理社会功能（次要结果）。我们假设，与强化护理相比，FFT-CHR 将在 18 个月内与 APS 和心理社会功能的更大改善相关。其次，6 个月内家庭沟通的改善将调节 18 个月内治疗状况与主要和次要结果之间的关系。预计 FFT-CHR 对精神病转化基线风险较高的个体的影响更大。试验结果将为精神病高危人群提供治疗指南。
Young people with attenuated psychotic symptoms (APS), brief intermittent psychosis, and/or genetic risk and functional deterioration are at high risk for developing psychotic disorders. In a prior trial, family-focused therapy for clinical high risk youth (FFT-CHR) was more effective than brief psychoeducation in reducing APS severity over 6 months. This 7-site trial will compare the efficacy of FFT-CHR to a psychoeducational and supportive intervention (enhanced care) on APS and social functioning in CHR individuals over 18 months. Participants (N = 220, ages 13–25 years) with a CHR syndrome will be randomly assigned to FFT-CHR (18 1-h sessions of family psychoeducation and communication/problem-solving skills training) or enhanced care (3 1-h family psychoeducational sessions followed by 5 individual support sessions), both given over 6 months. Participants will rate their weekly progress during treatment using a mobile-enhanced online platform. Family communication will be assessed in a laboratory interactional task at baseline and post-treatment. Independent evaluators will assess APS (primary outcome) and psychosocial functioning (secondary outcome) every 6 months over 18 months. We hypothesize that, compared to enhanced care, FFT-CHR will be associated with greater improvements in APS and psychosocial functioning over 18 months. Secondarily, improvements in family communication over 6 months will mediate the relationship between treatment condition and primary and secondary outcomes over 18 months. The effects of FFT-CHR are predicted to be greater in individuals with higher baseline risk for psychosis conversion. Results of the trial will inform treatment guidelines for individuals at high risk for psychosis.
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影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
5.9
作者：
Chambless, DL;Hollon, SD
通讯作者：
Hollon, SD
影响因子：
--
作者：
Charney, DS;Nemeroff, CB;Solomon, S
通讯作者：
Solomon, S
影响因子：
3.9
作者：
Benedict, RHB;Schretlen, D;Brandt, J
通讯作者：
Brandt, J
影响因子：
6.6
作者：
Ising, Helga K.;Kraan, Tamar C.;van der Gaag, Mark
通讯作者：
van der Gaag, Mark