Neuroblast migration along cellular substrates in the developing porcine brain.
Neuroblast migration along cellular substrates in the developing porcine brain.
复制标题
DOI：
10.1016/j.stemcr.2022.07.015
复制
发表时间：
2022-09-13
影响因子：
5.9
通讯作者：
Morton, Paul D.
中科院分区：
文献类型：
--
作者：
Porter, Demisha D. L.;Henry, Sara N.;Ahmed, Sadia;Rizzo, Amy L.;Makhlouf, Rita;Gregg, Collin;Morton, Paul D.
在过去的十年中，很明显，神经母细胞在出生后不久就通过独特的迁移流继续为人类皮层提供中间神经元。由于人脑的大小，这些新生神经元必须通过复杂的细胞景观长距离迁移才能到达最终位置。人们对这一过程知之甚少，主要是因为获取和研究神经典型死后人类样本的技术困难以及经过充分研究的小鼠模型的不同发育特征。我们推断神经母细胞的迁移流利用细胞基质（例如血管）来引导它们从脑室下区长途跋涉到远处的皮质目标。在这里，我们评估了相当于人类出生、婴儿期和幼儿期发育期间的环脑仔猪中年轻的神经元间迁移流与其首选细胞底物之间的关联。神经母细胞的迁移流在猪出生后发育过程中得到保留 迁移流中年轻新皮质中间神经元的证据 神经母细胞与血管和星形胶质细胞基质密切相关 迁移中间神经元或其基质的损害可能会产生终生后果 Porter 等人。评估了出生后仔猪脑室下区未成熟神经元（神经母细胞）的时空分布。多重标记显示，迁移的神经母细胞可能是源自腹侧胚胎前脑的皮质抑制性中间神经元。这些在产后仔猪中的发现为理解正常和患病状态下的神经元迁移和皮质发育提供了新的平台和观点。
In the past decade it has become evident that neuroblasts continue to supply the human cortex with interneurons via unique migratory streams shortly following birth. Owing to the size of the human brain, these newborn neurons must migrate long distances through complex cellular landscapes to reach their final locations. This process is poorly understood, largely because of technical difficulties in acquiring and studying neurotypical postmortem human samples along with diverging developmental features of well-studied mouse models. We reasoned that migratory streams of neuroblasts utilize cellular substrates, such as blood vessels, to guide their trek from the subventricular zone to distant cortical targets. Here, we evaluate the association between young interneuronal migratory streams and their preferred cellular substrates in gyrencephalic piglets during the developmental equivalent of human birth, infancy, and toddlerhood. Migratory streams of neuroblasts are preserved through postnatal swine development Evidence of young neocortical interneurons within migratory streams Neuroblasts are tightly associated with vascular and astrocytic cellular substrates Harm to migratory interneurons or their substrates may have lifelong consequences Porter et al. evaluated the spatiotemporal distribution of immature neurons (neuroblasts) in the subventricular zone of the postnatal piglet. Multiplex labeling revealed that migrating neuroblasts are likely cortical inhibitory interneurons originating from the ventral embryonic forebrain. These findings in the postnatal piglet provide a new platform and viewpoint for understanding neuronal migration and cortical development in normal and diseased states.
登录
查看更多内容
影响因子：
2.9
作者：
Costine BA;Missios S;Taylor SR;McGuone D;Smith CM;Dodge CP;Harris BT;Duhaime AC
通讯作者：
Duhaime AC
影响因子：
4.3
作者：
Gengatharan A;Bammann RR;Saghatelyan A
通讯作者：
Saghatelyan A
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
5.3
作者：
Bovetti, Serena;Hsieh, Yi-Chun;Puche, Adam C.
通讯作者：
Puche, Adam C.
影响因子：
2.9
作者：
Conrad MS;Dilger RN;Johnson RW
通讯作者：
Johnson RW