Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: a longitudinal MRI study.
Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: a longitudinal MRI study.
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DOI：
10.1159/000339311
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发表时间：
2012
影响因子：
2.9
通讯作者：
Johnson RW
中科院分区：
文献类型：
--
作者：
Conrad MS;Dilger RN;Johnson RW
一种大脑生长类似于人类的动物模型，可用于MRI研究，以研究大脑发育，将是有价值的。我们的实验室已经开发并验证了用于新生仔猪局部脑体积定量的MRI方法。本研究的目的是利用MRI为基础的体积定量技术在纵向研究，以确定从2至24周龄的家猪的脑生长。MRI数据采集自2至24周龄的猪，使用三维MPWS序列，在STIMTOM Trio 3 T成像仪上进行。进行手动分割以估计全脑、皮质、间脑、脑干、小脑和海马区域的体积。逻辑建模程序被用来表征大脑的生长。雄性和雌性动物的总脑体积从2周至24周分别增加130%（± 12%）和121%（± 7%）。最大的脑体积增加发生在4周龄左右，95%的全脑生长发生在21-23周龄。Logstrom模型表明，有性别的双态性影响大脑的生长。例如，在女性中，皮质较小（P = 0.04）。此外，海马的最大生长出现在女性比男性早约5周，和海马生长的窗口女性比男性显着短（P = 0.02，P = 0.002）。这些两性异形与在人类中看到的相似。除了为猪的大脑生长提供重要数据外，这项研究还表明猪可以用于获得纵向MRI数据。出生后脑体积的大幅增加与人类新生儿相似，表明猪可用于研究大脑发育。
An animal model with brain growth similar to humans, that can be used in MRI studies to investigate brain development, would be valuable. Our lab has developed and validated MRI methods for regional brain volume quantification in the neonatal piglet. The aim of this study was to utilize the MRI-based volume quantification technique in a longitudinal study to determine brain growth in domestic pigs from 2 to 24 wks of age. MRI data were acquired from pigs 2 to 24 wks of age using a three-dimensional MPRAGE sequence on a MAGNETOM Trio 3T imager. Manual segmentation was performed for volume estimates of total brain, cortical, diencephalon, brainstem, cerebellar, and hippocampal regions. Logistic modeling procedures were used to characterize brain growth. Total brain volume increased 130% (± 12%) and 121% (± 7%) from 2 to 24 wks in males and females, respectively. The maximum increase in total brain volume occurred about age 4 wks and 95% of whole brain growth occurred by age 21–23 wks. Logistical modeling suggests there are sexually dimorphic effects on brain growth. For example, in females, cortex was smaller (P = 0.04). Furthermore, the maximum growth of the hippocampus occurred about 5 wks earlier in females than males, and the window for hippocampal growth was significantly shorter in females than males (P = 0.02, P = 0.002 respectively). These sexual dimorphisms are similar to what is seen in humans. In addition to providing important data on brain growth for pigs, this study shows pigs can be used to obtain longitudinal MRI data. The large increase in brain volume in the postnatal period is similar to human neonates and suggests pigs can be used to investigate brain development.
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DOI：
10.1080/02841850802334224
发表时间：
2008-11
期刊：
Acta radiologica (Stockholm, Sweden : 1987)
影响因子：
--
作者：
Munkeby BH;De Lange C;Emblem KE;Bjørnerud A;Kro GA;Andresen J;Winther-Larssen EH;Løberg EM;Hald JK
通讯作者：
Hald JK
影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
5.7
作者：
Jelsing, J;Rostrup, E;Pakkenberg, B
通讯作者：
Pakkenberg, B
DOI：
10.1098/rspb.1967.0002
发表时间：
1967-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DICKERSON, JW;DOBBING, J
通讯作者：
DOBBING, J
影响因子：
--
作者：
Lieberman, JA;Tollefson, GD;Tohen, M
通讯作者：
Tohen, M