Restoration of upper limb movement via artificial corticospinal and musculospinal connections in a monkey with spinal cord injury.
Restoration of upper limb movement via artificial corticospinal and musculospinal connections in a monkey with spinal cord injury.
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DOI：
10.3389/fncir.2013.00057
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发表时间：
2013
影响因子：
3.5
通讯作者：
Fetz EE
中科院分区：
文献类型：
--
作者：
Nishimura Y;Perlmutter SI;Fetz EE
脊髓损伤或中风患者的肢体控制功能丧失可由皮质脊髓通路中断引起，尽管病变上方和下方的神经回路仍有功能。一种人工神经连接连接失去的通路并连接皮质和脊髓电路，有可能改善功能损失。我们研究了引入新的人工神经连接对瘫痪猴子的影响，该猴子在C2节段有单侧脊髓损伤。第一次应用桥接了受损的脊柱病变。这使得猴子可以通过运动前或运动皮质中高伽马活动的自愿控制力量来驱动脊髓刺激，从而获得一个力量匹配的靶子。第二个应用程序创建了一个从瘫痪的激动肌肉到脊髓部位的人工循环连接，允许肌肉控制的脊髓刺激来促进肌肉中持续的活动。这些结果提示，在脊髓损伤或中风等下行通路受损后，人工神经连接可以补偿中断的下行通路，促进对上肢运动的意志控制。
Functional loss of limb control in individuals with spinal cord injury or stroke can be caused by interruption of corticospinal pathways, although the neural circuits located above and below the lesion remain functional. An artificial neural connection that bridges the lost pathway and connects cortical to spinal circuits has potential to ameliorate the functional loss. We investigated the effects of introducing novel artificial neural connections in a paretic monkey that had a unilateral spinal cord lesion at the C2 level. The first application bridged the impaired spinal lesion. This allowed the monkey to drive the spinal stimulation through volitionally controlled power of high-gamma activity in either the premotor or motor cortex, and thereby to acquire a force-matching target. The second application created an artificial recurrent connection from a paretic agonist muscle to a spinal site, allowing muscle-controlled spinal stimulation to boost on-going activity in the muscle. These results suggest that artificial neural connections can compensate for interrupted descending pathways and promote volitional control of upper limb movement after damage of descending pathways such as spinal cord injury or stroke.
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影响因子：
64.8
作者：
Ethier, C.;Oby, E. R.;Bauman, M. J.;Miller, L. E.
通讯作者：
Miller, L. E.
影响因子：
64.8
作者：
Moritz, Chet T.;Perlmutter, Steve I.;Fetz, Eberhard E.
通讯作者：
Fetz, Eberhard E.
DOI：
10.3389/fneng.2010.00006
发表时间：
2010
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Krüger J;Caruana F;Volta RD;Rizzolatti G
通讯作者：
Rizzolatti G
DOI：
10.1109/tnsre.2006.875547
发表时间：
2006-06-01
影响因子：
4.9
作者：
Jackson, Andrew;Moritz, Chet T.;Fetz, Eberhard E.
通讯作者：
Fetz, Eberhard E.
影响因子：
5.3
作者：
Miller, K. J.;Zanos, S.;Ojemann, J. G.
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Ojemann, J. G.