Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients
Association of Serum Uric Acid with Arterial Stiffness in Peritoneal Dialysis Patients
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腹膜透析患者血清尿酸与动脉僵硬度的关系
DOI：
10.1159/000493659
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发表时间：
2018-09
影响因子：
2.8
通讯作者：
Yang Xiao
中科院分区：
文献类型：
--
作者：
Liu Xinhui;Wu Juan;Wu Haishan;Yi Chunyan;Huang Fengxian;Yu Xueqing;Yang Xiao
背景/目的：血清尿酸（SUA）被认为是与心血管风险和动脉僵硬度增加相关的介质。然而，关于腹膜透析 (PD) 患者 SUA 与动脉僵硬度之间关系的证据尚缺乏。本研究的目的是探讨帕金森病患者 SUA 与动脉僵硬度之间的关系。方法：纳入2014年1月1日至2016年10月31日进行血管造影测试并具有SUA值的患者。通过臂踝脉搏波速度（baPWV）评估动脉僵硬度。通过多元线性回归模型测试SUA和baPWV之间的关系。结果：645 名 PD 患者中，平均 SUA 为 6.80 (±1.29) mg/dL，平均 baPWV 为 1713 (±505) cm/s。在完全调整的线性回归模型中，年轻人中较高的 SUA 与较高的 baPWV 显着相关[标准化系数 (β)，0.085； 95%置信区间（95% CI），0.013至0.130； P=0.02]但老年PD患者则不然（β，-0.194；95% CI，-0.774至0.093；P=0.1）。在年轻患者的性别分层模型中，男性的 SUA 和 baPWV 之间存在显着相关性（β，0.115；95% CI，0.015 至 0.182；P=0.02），但女性则不然。性别特异性 SUA 最高四分位的男性的 baPWV 高于最低四分位的男性（β，0.132；95% CI，0.011 至 0.209；P=0.03）。当选择 SUA 水平较低的男性患者（四分位数 1 和 2）和 SUA 水平较高的女性患者（四分位数 3 和 4）时，这种性别差异发生了逆转。结论：年轻PD患者中SUA与baPWV呈正相关，且这种相关性在男性中显着，但在女性中不显着，这可能是由于男性SUA水平高于女性所致。
Background/Aims: Serum uric acid (SUA) has been proposed as a mediator associated with increased cardiovascular risk and arterial stiffness. However, evidence on the association between SUA and arterial stiffness in peritoneal dialysis (PD) patients is lacking. The aim of this study was to examine the relationship between SUA and arterial stiffness in PD patients. Methods: The patients who performed vascular profiler test from January 1, 2014 to October 31, 2016, and with SUA values were enrolled. Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). The relationship between SUA and baPWV was tested by multiple linear regression models. Results: Of 645 PD patients, mean SUA was 6.80 (±1.29) mg/dL, mean baPWV was 1713 (±505) cm/s. In fully adjusted linear regression models, higher SUA was significantly associated with higher baPWV in young [standardized coefficients (β), 0.085; 95% confidence interval (95% CI), 0.013 to 0.130; P=0.02] but not in elderly (β, -0.194; 95% CI, -0.774 to 0.093; P=0.1) PD patients. In gender-stratified models of young patients, there was a significant association between SUA and baPWV in male (β, 0.115; 95% CI, 0.015 to 0.182; P=0.02) but not in female. Male in the highest gender-specific SUA quartile had a higher baPWV than those in the lowest quartile (β, 0.132; 95% CI, 0.011 to 0.209; P=0.03). This gender difference was reversed when selecting male patients with lower SUA levels (quartile 1 and 2) and female patients with higher SUA levels (quartile 3 and 4). Conclusion: SUA was positively associated with baPWV in young PD patients, and this association was significant in males but not in females, which is possibly explained by the higher SUA level in males than in females.
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DOI：
10.3904/kjim.2013.28.4.464
发表时间：
2013-07
期刊：
The Korean journal of internal medicine
影响因子：
--
作者：
Avramovski P;Janakievska P;Sotiroski K;Sikole A
通讯作者：
Sikole A
影响因子：
5.4
作者：
Jie Zhang;G. Xiang;L. Xiang;H. Sun
通讯作者：
Jie Zhang;G. Xiang;L. Xiang;H. Sun
影响因子：
4.9
作者：
Tanaka, Hirofumi;Munakata, Masanori;Ozawa, Toshio
通讯作者：
Ozawa, Toshio
影响因子：
5.3
作者：
Fang, Jo-I;Wu, Jin-Shang;Chang, Chih-Jen
通讯作者：
Chang, Chih-Jen
影响因子：
13.6
作者：
Kang, DH;Park, SK;Johnson, RJ
通讯作者：
Johnson, RJ