Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.
Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer.
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DOI：
10.1186/s12876-021-01635-6
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发表时间：
2021-02-10
影响因子：
2.4
通讯作者：
Guo X
中科院分区：
文献类型：
--
作者：
Chen J;Li H;Xu W;Guo X
胰腺癌（PC）是一种预后不良的毁灭性疾病，5年总生存率约为5%。PC预后不良的部分原因是由于缺乏合适的生物标志物，可以允许早期诊断。溶血磷脂酶autotaxin （ATX）及其产物溶血磷脂酸（LPA）在PC患者的疾病进展中起重要作用，并与几种类型癌症的发病率增加有关。在这项研究中，我们评估了血清LPA和ATX作为PC诊断标志物的潜在作用，以及它们单独或联合CA19-9对PC的预后价值。采用ELISA法检测PC患者（114例）、健康志愿者（120例）和良性胰腺疾病患者（94例）血清中ATX、LPA和CA19-9水平。PC患者血清ATX、LPA和CA19-9水平显著高于BPD患者或HVs （p < 0.001）。LPA对早期PC的敏感性为91.74%，ATX的特异性为80%。早期PC患者的ATX、LPA和CA19-9水平均明显高于BPD患者和hv患者的血清水平。ATX和LPA的加入可显著提高CA19-9对PC的诊断效能（p = 0.0012）。检测LPA和ATX水平以及CA19-9水平可用于PC的早期发现和诊断。
Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of suitable biomarkers that can allow early diagnosis. The lysophospholipase autotaxin (ATX) and its product lysophosphatidic acid (LPA) play an essential role in disease progression in PC patients and are associated with increased morbidity in several types of cancer. In this study, we evaluated both the potential role of serum LPA and ATX as diagnostic markers in PC and their prognostic value for PC either alone or in combination with CA19-9. ATX, LPA and CA19-9 levels were evaluated using ELISA of serum obtained from PC patients (n = 114) healthy volunteers (HVs: n = 120) and patients with benign pancreatic diseases (BPDs: n = 94). Serum levels of ATX, LPA and CA19-9 in PC patients were substantially higher than that for BPD patients or HVs (p < 0.001). The sensitivity of LPA in early phase PC was 91.74% and the specificity of ATX was 80%. The levels of ATX, LPA and CA19-9 were all substantially higher for early stage PC patients compared to levels in serum from BPD patients and HVs. The diagnostic efficacy of CA19-9 for PC was significantly enhanced by the addition of ATX and LPA (p = 0.0012). Measurement of LPA and ATX levels together with CA19-9 levels can be used for early detection of PC and diagnosis of PC in general.
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影响因子：
1.6
作者：
Kazama, Shinsuke;Kitayama, Joji;Nagawa, Hirokazu
通讯作者：
Nagawa, Hirokazu
影响因子：
3.6
作者：
Stuart, Charlotte E. A.;Singh, Ruma G.;Petrov, Maxim S.
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Petrov, Maxim S.
影响因子：
4.8
作者：
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通讯作者：
Inoue, K
影响因子：
2
作者：
Banfi, G;Bravi, S;Zerbi, A
通讯作者：
Zerbi, A
影响因子：
3.7
作者：
Fukushima, Kaori;Takahashi, Kaede;Tsujiuchi, Toshifumi
通讯作者：
Tsujiuchi, Toshifumi