Nerve growth factor: an update on the science and therapy.
Nerve growth factor: an update on the science and therapy.
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DOI：
10.1016/j.joca.2013.06.004
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发表时间：
2013-09
影响因子：
7
通讯作者：
Lane, N. E.
中科院分区：
文献类型：
--
作者：
Seidel, M. F.;Wise, B. L.;Lane, N. E.
神经生长因子（NGF）是伤害性疼痛的关键调节因子，因此似乎是一类创新的镇痛药物的一个有趣的靶分子。我们着手审查的原则，神经源性炎症和结果的抗神经生长因子方案在动物研究以及临床试验与患者的背痛和骨关节炎（OA）。我们使用Google Scholar Search和Pubmed以及会议报告检索与NGF和使用抗NGF方案的临床试验相关的文章和摘要。我们在这篇综述中报告了与这些药物相关的疗效结果和不良事件（AE）。我们确定了五篇完整的文章和八个抽象的报告，研究抗神经生长因子药物用于背痛和OA。在许多膝关节和髋关节疼痛试验中，与单独使用NSAID相比，单独使用抗NGF药物或与非甾体抗炎药（NSAID）联合使用抗NGF药物治疗疼痛更有效。然而，包括快速进展的OA和关节置换在内的不良反应在接受抗NGF和NSAID治疗的患者中比单独治疗更常见。抗神经生长因子治疗相关的神经系统症状，包括感觉异常，和潜在的其他类型的不良反应通常是短暂的，但需要额外的调查。
Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative class of analgesic medication. We set out to review the principles of neurogenic inflammation and results of anti-NGF regimens in animal studies as well as clinical trials with patients with back pain and osteoarthritis (OA). We searched using Google Scholar Search and Pubmed as well as through conference reports for articles and abstracts related to NGF and clinical trials using anti-NGF regimens. We report on efficacy findings and adverse events (AEs) related to these agents in this review. We identified five full articles and eight abstract reports relating to anti-NGF agents studied for use in back pain and in OA. Anti-NGF agents either alone or in combination with non-steroidal anti-inflammatory agents (NSAIDs) were more efficacious for the treatment of pain in a number of trials of knee and hip pain compared to NSAIDs alone. However, adverse effects that included rapidly progressive OA and joint replacement were more common in patients treated with anti-NGF and NSAIDs than either treatment alone. Anti-NGF treatment related neurologic symptoms including paresthesias, and potentially other types of adverse effects were usually transient but warrant additional investigation.
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DOI：
10.1056/nejmoa0901510
发表时间：
2010-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lane NE;Schnitzer TJ;Birbara CA;Mokhtarani M;Shelton DL;Smith MD;Brown MT
通讯作者：
Brown MT
DOI：
10.3415/vcot-10-04-0051
发表时间：
2011-01-01
影响因子：
1.3
作者：
Isola, M.;Ferrari, V.;Busetto, R.
通讯作者：
Busetto, R.
影响因子：
64.8
作者：
LINDSAY, RM;HARMAR, AJ
通讯作者：
HARMAR, AJ
影响因子：
7.4
作者：
McNamee, Kay E.;Burleigh, Annika;Inglis, Julia J.
通讯作者：
Inglis, Julia J.
DOI：
10.1073/pnas.80.23.7215
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GEE, AP;BOYLE, MDP;YOUNG, M
通讯作者：
YOUNG, M