Drug Combinations against Mucor irregularis In Vitro

Drug Combinations against Mucor irregularis In Vitro
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体外抗不规则毛霉的药物组合

DOI:
10.1128/aac.02612-12
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发表时间:
2013-04
影响因子:
4.9
通讯作者:
Yu, Jin
Yu, Jin
中科院分区:
医学2区
文献类型:
--
作者:
Zhang, Shuzhen;Li, Ruoyu;Yu, Jin

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摘要研究了特比萘芬或卡泊芬净与阿替霉素B、泊沙康唑或伊曲康唑的组合对18株不规则毛霉的体外治疗作用。观察到特比萘芬与阿替霉素B、泊沙康唑和伊曲康唑的组合对38.9%、33.3%和44.4%的所研究菌株的协同作用。相比之下,观察到卡泊芬净与阿替霉素B、泊沙康唑和伊曲康唑的组合对99.4%、66.7%和99.4%的所研究菌株的协同作用。此外,未观察到拮抗作用。
ABSTRACT Combinations of terbinafine or caspofungin with amphotericin B, posaconazole, or itraconazole were studied as potential treatments against 18 isolates of Mucor irregularis in vitro. Synergism of the combinations of terbinafine with amphotericin B, posaconazole, and itraconazole against 38.9, 33.3, and 44.4% of the strains studied was observed. In contrast, synergism of the combinations of caspofungin with amphotericin B, posaconazole, and itraconazole against 99.4, 66.7, and 99.4% of the strains studied was observed. Furthermore, no antagonism was observed.
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