Glia selectively approach synapses on thin dendritic spines.

Glia selectively approach synapses on thin dendritic spines.
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DOI:
10.1098/rstb.2014.0047
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发表时间:
2014-10-19
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
Stewart MG
Stewart MG
中科院分区:
其他
文献类型:
--
作者:
Medvedev N;Popov V;Henneberger C;Kraev I;Rusakov DA;Stewart MG

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This paper examines the relationship between the morphological modality of 189 dendritic spines and the surrounding astroglia using full three-dimensional reconstructions of neuropil fragments. An integrative measure of three-dimensional glial coverage confirms that thin spine postsynaptic densities are more tightly surrounded by glia. This distinction suggests that diffusion-dependent synapse–glia communication near ‘learning’ synapses (associated with thin spines) could be stronger than that near ‘memory’ synapses (associated with larger spines).
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