Determination of the Plasmodium vivax relapse pattern in Camopi, French Guiana.
Determination of the Plasmodium vivax relapse pattern in Camopi, French Guiana.
复制标题
DOI：
10.1186/1475-2875-8-278
复制
发表时间：
2009-12-04
期刊：
影响因子：
3
通讯作者：
Carme B
中科院分区：
文献类型：
--
作者：
Hanf M;Stéphani A;Basurko C;Nacher M;Carme B
疟疾是法属圭亚那的一个主要公共卫生问题，自2000年以来，间日疟原虫已成为主要的疟疾物种。如同在其他流行地区一样，重要的是要具体说明间日疟复发的模式，并努力有效地区分再次感染和复发。这项研究是在2001年1月1日至2008年12月31日期间出生在Camopi的儿童中进行的，Camopi是一个位于亚马逊森林的美洲印第安人村庄（n = 325），采用开放队列设计。采用生存分析法计算间日疟原虫的原发和继发发病率。利用原发率和继发率的差异，间接估计间日疟原虫的复发率，并评估其时间演变。在记录的1042例疟疾发作中，689例（66%）是由于间日疟原虫（无混合感染）。151名儿童初次感染间日疟原虫，106名儿童两次首次感染间日疟原虫。在没有伯氨喹治疗的情况下，结果表明间日疟原虫复发主要发生在首次发作后的前三个月。30%的儿童从未复发，42%在初次发作后的第一个月前复发，59%在第二个月前复发，63%在第三个月前复发。本研究证实，Camopi的复发模式与间日疟原虫Chesson（热带）菌株的复发模式一致。此外，由于复发率的时间演变，可以构建一个简单的任意分类规则：初次发作后90天之前，二次发作是复发; 90天之后，是再感染。可以根据这些结果设计适应性疟疾病例管理。
Malaria is a major public health problem in French Guiana, where Plasmodium vivax has become the dominant malaria species since 2000. As in others endemic areas, it is important to specify the pattern of vivax malaria relapses and to try to discriminate efficiently re-infections from relapses. This study was conducted in children born between January 1, 2001 and December 31, 2008 in Camopi, an Amerindian village located in the Amazon forest (n = 325), using an open cohort design. Primary and secondary attack rates of P. vivax were calculated using survival analysis. With the difference between the primary and secondary rates, this study aimed to estimate indirectly P. vivax relapse rate and evaluate its time evolution. Of the 1042 malaria attacks recorded, 689 (66%) were due to P. vivax (without mixed infection). One hundred and fifty one children had their primary attack with P. vivax and 106 had their two first attacks with P. vivax. In the absence of primaquine treatment, it was shown that P. vivax relapses mainly occurred during the first three months after the first attack. Thirty percent of children never had a relapse, 42% had a relapse before the first month after primary attack, 59% before the second month and 63% before the third month. This study confirmed that the relapse pattern in Camopi was compatible with the pattern described for the P. vivax Chesson (tropical) strain. In addition, due to the relapse rate time evolution, a simple arbitrary classification rule could be constructed: before 90 days after the primary attack, the secondary attack is a relapse; after 90 days, it is a re-infection. Adapted management of malaria cases based on these results could be devised.
登录
查看更多内容
影响因子：
11.8
作者：
Kochar DK;Saxena V;Singh N;Kochar SK;Kumar SV;Das A
通讯作者：
Das A
DOI：
10.4269/ajtmh.2001.64.97
发表时间：
2001-01-01
影响因子：
3.3
作者：
Mendis, K;Sina, BJ;Carter, R
通讯作者：
Carter, R
影响因子：
2.7
作者：
Abeku, TA;van Oortmarssen, GJ;Habbema, JDF
通讯作者：
Habbema, JDF
影响因子：
6.4
作者：
Kirchgatter, K;del Portillo, HA
通讯作者：
del Portillo, HA
DOI：
10.4269/ajtmh.1980.29.725
发表时间：
1980-01-01
影响因子：
3.3
作者：
MOLINEAUX, L;STOREY, J;THOMAS, A
通讯作者：
THOMAS, A