Distinct frontal lobe morphology in girls and boys with ADHD.
Distinct frontal lobe morphology in girls and boys with ADHD.
复制标题
DOI：
10.1016/j.nicl.2014.12.010
复制
发表时间：
2015
影响因子：
4.2
通讯作者：
Mostofsky, Stewart H.
中科院分区：
文献类型：
--
作者：
Dirlikov, Benjamin;Rosch, Keri Shiels;Crocetti, Deana;Denckla, Martha B.;Mahone, E. Mark;Mostofsky, Stewart H.
本研究调查了患有ADHD（8-12岁）的男孩和女孩与正常发育（TD）同龄人相比，额叶皮质形态是否不同。参与者包括226名8-12岁的儿童，包括93名ADHD儿童（29名女孩）和133名TD儿童（42名女孩），他们获得了3 T MP3 MRI扫描。使用全自动额叶图谱生成功能不同的额叶分区，评估每个区域的表面积（SA）和皮质厚度（CT）。分析的重点是整体诊断差异，以及检查诊断的影响，男孩和女孩。患有ADHD的女孩，而不是男孩，表现出总的前额叶皮层（PFC）SA的整体减少。本地化显示，女孩表现出广泛分布的减少，在双边背外侧PFC，左下外侧PFC，右内侧PFC，右眶额皮质，左前扣带;和男孩只在右前扣带和左内侧PFC减少SA。相反，男孩，但不是女孩，ADHD表现出整体减少运动前皮质（PMC）SA。进一步定位显示，男孩的双侧外侧PMC区域观察到运动前区减少;女孩的双侧补充运动复合体观察到减少。在诊断组的差异，PMC和PFC SA与ADHD的女孩和男孩的症状严重程度呈负相关。这些结果阐明了额叶功能分区的皮质形态的性别差异，并提供了额外的证据之间的关联SA和ADHD儿童的症状严重程度。患有ADHD的儿童表现出皮质表面积减少。患有ADHD的男孩表现出运动前区皮质总表面积的总体减少。患有ADHD的女孩表现出前额皮质总表面积的总体减少。ADHD组的表面积与症状严重程度相关。
This study investigated whether frontal lobe cortical morphology differs for boys and girls with ADHD (ages 8–12 years) in comparison to typically developing (TD) peers. Participants included 226 children between the ages of 8–12 including 93 children with ADHD (29 girls) and 133 TD children (42 girls) for which 3T MPRAGE MRI scans were obtained. A fully automated frontal lobe atlas was used to generate functionally distinct frontal subdivisions, with surface area (SA) and cortical thickness (CT) assessed in each region. Analyses focused on overall diagnostic differences as well as examinations of the effect of diagnosis within boys and girls. Girls, but not boys, with ADHD showed overall reductions in total prefrontal cortex (PFC) SA. Localization revealed that girls showed widely distributed reductions in the bilateral dorsolateral PFC, left inferior lateral PFC, right medial PFC, right orbitofrontal cortex, and left anterior cingulate; and boys showed reduced SA only in the right anterior cingulate and left medial PFC. In contrast, boys, but not girls, with ADHD showed overall reductions in total premotor cortex (PMC) SA. Further localization revealed that in boys, premotor reductions were observed in bilateral lateral PMC regions; and in girls reductions were observed in bilateral supplementary motor complex. In line with diagnostic group differences, PMC and PFC SAs were inversely correlated with symptom severity in both girls and boys with ADHD. These results elucidate sex-based differences in cortical morphology of functional subdivisions of the frontal lobe and provide additional evidence of associations among SA and symptom severity in children with ADHD. Children with ADHD showed reductions in cortical surface area. Boys with ADHD showed overall reductions in total premotor cortex surface area. Girls with ADHD showed overall reductions in total prefrontal cortex surface area. Surface area in the ADHD group was associated with symptom severity.
登录
查看更多内容
影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
1.5
作者：
Ewen, Joshua B.;Moher, Jeffrey S.;Mahone, E. Mark
通讯作者：
Mahone, E. Mark
影响因子：
9.9
作者：
Cole, W. R.;Mostofsky, S. H.;Larson, J. C. Gidley;Denckla, M. B.;Mahone, E. M.
通讯作者：
Mahone, E. M.
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL