Complexity and challenges in defining myeloid-derived suppressor cells.
Complexity and challenges in defining myeloid-derived suppressor cells.
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定义骨髓源性抑制细胞的复杂性和挑战。
DOI：
10.1002/cyto.b.21206
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Mandruzzato, Susanna
中科院分区：
文献类型：
--
作者：
Damuzzo, Vera;Pinton, Laura;Desantis, Giacomo;Solito, Samantha;Marigo, Ilaria;Bronte, Vincenzo;Mandruzzato, Susanna
对具有抑制活性的骨髓细胞的研究是一个活跃的研究领域，鉴于这些细胞对宿主免疫应答的负调节能力，其在癌症中具有特别重要的意义。这些细胞的扩增，称为骨髓源性抑制细胞（MDSC），已在许多荷瘤小鼠模型和各种来源的肿瘤患者中记录，它们的存在与疾病进展和生存期降低相关。出于这个原因，监测这种类型的细胞扩增具有临床重要性，流式细胞术是其鉴定的首选技术。多年来，已经证明MDSC包含一组属于单核细胞和粒细胞谱系的未成熟骨髓细胞，具有几个分化阶段;它们的发生取决于肿瘤来源的可溶性因子，这些因子指导它们的扩增并决定它们的分化阻断。由于其组成的异质性，这些细胞的准确表型需要一种快速的方法，以便所有MDSC亚群的扩增都可以得到赞赏。这篇综述文章的重点是识别MDSCs，并讨论了与人类和小鼠模型中的表型循环和肿瘤相关MDSCs相关的问题。© 2014作者Cytometry Part B：Clinical Cytometry由Wiley Periodicals，Inc.出版。
Study of myeloid cells endowed with suppressive activity is an active field of research which has particular importance in cancer, in view of the negative regulatory capacity of these cells to the host's immune response. The expansion of these cells, called myeloid-derived suppressor cells (MDSCs), has been documented in many models of tumor-bearing mice and in patients with tumors of various origin, and their presence is associated with disease progression and reduced survival. For this reason, monitoring this type of cell expansion is of clinical importance, and flow cytometry is the technique of choice for their identification. Over the years, it has been demonstrated that MDSCs comprise a group of immature myeloid cells belonging both to monocytic and granulocytic lineages, with several stages of differentiation; their occurrence depends on tumor-derived soluble factors, which guide their expansion and determine their block of differentiation. Because of their heterogeneous composition, accurate phenotyping of these cells requires a multicolor approach, so that the expansion of all MDSC subsets can be appreciated. This review article focuses on identifying MDSCs and discusses problems associated with phenotyping circulating and tumor-associated MDSCs in humans and in mouse models. © 2014 The Authors Cytometry Part B: Clinical Cytometry Published by Wiley Periodicals, Inc.
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影响因子：
7.3
作者：
De Sanctis F;Sandri S;Ferrarini G;Pagliarello I;Sartoris S;Ugel S;Marigo I;Molon B;Bronte V
通讯作者：
Bronte V
影响因子：
48
作者：
Aghaeepour N;Finak G;FlowCAP Consortium;DREAM Consortium;Hoos H;Mosmann TR;Brinkman R;Gottardo R;Scheuermann RH
通讯作者：
Scheuermann RH
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
DOI：
10.1073/pnas.1113744109
发表时间：
2012-02-14
影响因子：
11.1
作者：
Cortez-Retamozo, Virna;Etzrodt, Martin;Pittet, Mikael J.
通讯作者：
Pittet, Mikael J.
影响因子：
10.1
作者：
Chavan R;Salvador D;Gustafson MP;Dietz AB;Nevala W;Markovic SN
通讯作者：
Markovic SN