Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
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DOI：
10.3390/cancers13010045
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发表时间：
2020-12-25
期刊：
影响因子：
5.2
通讯作者：
Faden DL
中科院分区：
文献类型：
--
作者：
Chang Sing Pang KJW;Mur T;Collins L;Rao SR;Faden DL
人乳头瘤病毒（HPV）在鼻腔鼻窦鳞状细胞癌（SNSCC）中的致病作用尚不清楚，并且受到使用可变HPV检测技术的小型研究的阻碍。这项荟萃分析旨在提供一个更新的概述HPV的流行率在SNSCC分层的检测方法，解剖亚位点，和地理区域。从60项合格的研究中，总体HPV患病率估计为26%。当按检测方法分层时，与单一底物检测相比，使用多底物检测时HPV患病率较低。与低暴露亚部位相比，高暴露于分泌流的亚部位的解剖亚部位HPV患病率更高。SNSCC中HPV的患病率遵循HPV+口咽鳞状细胞癌的全球分布。总之，这项荟萃分析进一步支持HPV在SNSCC亚组中的作用。人乳头瘤病毒（HPV）驱动口咽鳞状细胞癌（OPSCC）的一个子集中的肿瘤发生，并且在世界范围内的患病率正在增加。越来越多的证据表明，HPV也参与了鼻窦鳞状细胞癌（SNSCC）的一个子集，但现有文献中的小样本量和HPV检测技术的可变性阻碍了明确的结论。通过使用PubMed、Embase和Web of Science Core Collection数据库检索截至2020年3月29日的文献，进行了一项系统综述。两名作者独立遵循系统性综述和荟萃分析的首选报告项目（PRISMA）指南。采用随机效应模型进行荟萃分析。60项研究（n = 1449）有资格进行统计分析，估计总体HPV患病率为25.5%（95% CI 20.7-31.0）。当按HPV检测方法分层时，（20.5%，95% CI 14.5-28.2）低于单一底物检测（31.7%，95% CI 23.6-41.1），在高暴露解剖子部位中最高（鼻腔和筛窦）（37.6%，95% CI 26.5-50.2）vs.低暴露（15.1%，95% CI 7.3-28.6），HPV+ OPSCC高患病率地理区域最高（北美）（30.9%，95% CI 21.9-41.5）与低（非洲）（13.1，95% CI 6.5-24.5））。虽然小样本量和数据云的可变性确定了结论，但在这里，我们提供了SNSCC中HPV患病率的新参考点，沿着正交数据支持病毒驱动的肿瘤发生的致病作用，包括HPV更常见于暴露于反流口咽分泌物增加的鼻窦亚部位和HPV+ OPSCC更流行的地理区域。
The causative role of human papillomavirus (HPV) in sinonasal squamous cell carcinoma (SNSCC) remains unclear and is hindered by small studies using variable HPV detection techniques. This meta-analysis aims to provide an updated overview of HPV prevalence in SNSCC stratified by detection method, anatomic subsite, and geographic region. From 60 eligible studies, an overall HPV prevalence was estimated at 26%. When stratified by detection method, HPV prevalence was lower when using multiple substrate testing compared to single substrate testing. Anatomic subsite HPV prevalence was higher in subsites with high exposure to secretion flow compared to low exposure subsites. HPV prevalence in SNSCC followed the global distribution of HPV+ oropharyngeal squamous cell carcinoma. Taken together, this meta-analysis further supports a role for HPV in a subset of SNSCCs. Human papillomavirus (HPV) drives tumorigenesis in a subset of oropharyngeal squamous cell carcinomas (OPSCC) and is increasing in prevalence across the world. Mounting evidence suggests HPV is also involved in a subset of sinonasal squamous cell carcinomas (SNSCC), yet small sample sizes and variability of HPV detection techniques in existing literature hinder definitive conclusions. A systematic review was performed by searching literature through March 29th 2020 using PubMed, Embase, and Web of Science Core Collection databases. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed by two authors independently. A meta-analysis was performed using the random-effects model. Sixty studies (n = 1449) were eligible for statistical analysis estimating an overall HPV prevalence of 25.5% (95% CI 20.7–31.0). When stratified by HPV detection method, prevalence with multiple substrate testing (20.5%, 95% CI 14.5–28.2) was lower than with single substrate testing (31.7%, 95% CI 23.6–41.1), highest in high-exposure anatomic subsites (nasal cavity and ethmoids) (37.6%, 95% CI 26.5–50.2) vs. low-exposure (15.1%, 95% CI 7.3–28.6) and highest in high HPV+ OPSCC prevalence geographic regions (North America) (30.9%, 95% CI 21.9–41.5) vs. low (Africa) (13.1, 95% CI 6.5–24.5)). While small sample sizes and variability in data cloud firm conclusions, here, we provide a new reference point prevalence for HPV in SNSCC along with orthogonal data supporting a causative role for virally driven tumorigenesis, including that HPV is more commonly found in sinonasal subsites with increased exposure to refluxed oropharyngeal secretions and in geographic regions where HPV+ OPSCC is more prevalent.
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DOI：
10.2500/105065897782537160
发表时间：
1997-03-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
--
作者：
Bernauer, S;Welkoborsky, HJ;Mann, WJ
通讯作者：
Mann, WJ
DOI：
10.1002/hed.24391
发表时间：
2016-04-01
影响因子：
2.9
作者：
Becker, Christoph;Kayser, Gian;Pfeiffer, Jens
通讯作者：
Pfeiffer, Jens
影响因子：
3.4
作者：
BECK, JC;MCCLATCHEY, KD;BRADFORD, CR
通讯作者：
BRADFORD, CR
影响因子：
2.4
作者：
But-Hadzic, Jasna;Jenko, Klemen;Strojan, Primoz
通讯作者：
Strojan, Primoz
影响因子：
5.6
作者：
Bishop, Justin A.;Guo, Theresa W.;Westra, William H.
通讯作者：
Westra, William H.