Reduced cortical thickness in abstinent alcoholics and association with alcoholic behavior.
Reduced cortical thickness in abstinent alcoholics and association with alcoholic behavior.
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DOI：
10.1111/j.1530-0277.2011.01576.x
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
McGlinchey RE
中科院分区：
文献类型：
--
作者：
Fortier CB;Leritz EC;Salat DH;Venne JR;Maksimovskiy AL;Williams V;Milberg WP;McGlinchey RE
长期滥用酒精会对大脑造成广泛的损害。先前的形态计量学研究已经检查了酒精中毒个体的皮质萎缩；然而，以前没有研究使用皮质厚度测量来检测酒精相关的萎缩，以获得整个皮质表面组织损失的区域地图。我们比较了31名有酒精滥用史的戒酒者和34名健康的非酒精对照者（总样本量= 65）的皮质厚度测量值。从高分辨率t1加权图像中创建皮层表面模型，然后根据灰质/白质边界与皮层外表面之间的距离估计皮层厚度。与不酗酒的参与者相比，戒酒者的全脑厚度减少。双侧(i)额上区、（ii）中央前区、（iii）中央后区、（iv）额中区、(v)颞中/颞上区、（vi）颞中区和（vii）枕侧皮质区厚度减少。酒精组的皮质厚度减少与酒精滥用的严重程度有关。这些发现表明，慢性酒精中毒导致皮质厚度广泛减少，其中额叶和颞叶脑区减少最严重。
Chronic misuse of alcohol results in widespread damage to the brain. Prior morphometric studies have examined cortical atrophy in individuals with alcoholism; however, no previous studies have examined alcohol-associated atrophy using cortical thickness measurements to obtain regional mapping of tissue loss across the full cortical surface. We compared cortical thickness measures from 31 abstinent individuals with a history of prior alcohol abuse to 34 healthy nonalcoholic control participants (total sample size = 65). Cortical surface models were created from high-resolution T1-weighted images, and cortical thickness was then estimated as the distance between the gray matter/white matter boundary and the outer cortical surface. Abstinent alcoholics showed reduced whole-brain thickness as compared to nonalcoholic participants. Decreases in thickness were found bilaterally in (i) superior frontal, (ii) precentral, (iii) postcentral, (iv) middle frontal, (v) middle/superior temporal, (vi) middle temporal, and (vii) lateral occipital cortical regions. Decreased cortical thickness in the alcoholic group was associated with severity of alcohol abuse. These findings demonstrate widespread reduction in cortical thickness as a consequence of chronic alcoholism, with most severe reductions in frontal and temporal brain regions.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1111/j.1530-0277.2009.01079.x
发表时间：
2010-01-01
影响因子：
3.2
作者：
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通讯作者：
Barakos, Jerome
影响因子：
11
作者：
HARPER, C;KRIL, J
通讯作者：
KRIL, J
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
5.7
作者：
Fischl, B;Salat, DH;Dale, AM
通讯作者：
Dale, AM