Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case-control study.
Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case-control study.
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DOI：
10.1186/s12968-022-00887-9
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发表时间：
2022-09-12
期刊：
影响因子：
--
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中科院分区：
文献类型：
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2019年冠状病毒病后（长COVID-19）综合征的潜在病理生理学仍然未知，但心脏代谢需求增加和线粒体功能障碍状态已成为候选机制。心血管磁共振（CMR）提供了深入了解心血管疾病的病理生理机制和31-磷CMR光谱（31 P-CMRS）允许心肌能量状态的非侵入性评估。该研究的主要目的是评估长期COVID-19综合征是否与心肌结构、功能、灌注和能量代谢异常相关。前瞻性病例对照研究。共有20例临床诊断为长期COVID-19综合征（血清学阳性）且既往无基础心血管疾病（CVD）的患者和10例匹配的健康对照在单个时间点接受了3 T下的31 P-CMRS和CMR。所有患者都有急性COVID-19的症状，但没有人需要住院。在长COVID-19综合征患者和匹配的当代健康对照之间，心肌能量学（磷酸肌酸与ATP的比率）、心脏结构（双心室容积）、功能（双心室射血分数、整体纵向应变）、组织表征（T1标测和晚期钆增强）或灌注（心肌静息和应激血流、心肌灌注储备）没有差异。1例长COVID-19综合征患者在晚期钆增强成像上显示心外膜下增强，与既往心肌炎一致，但心脏大小、功能、灌注、细胞外容积分数、天然T1、T2或心脏能量学无伴随异常。在这项前瞻性病例对照研究中，绝大多数患有临床长期COVID-19综合征且既往无CVD的患者在心肌能量学、结构、功能、血流或组织特征方面均未表现出任何异常。
The underlying pathophysiology of post-coronavirus disease 2019 (long-COVID-19) syndrome remains unknown, but increased cardiometabolic demand and state of mitochondrial dysfunction have emerged as candidate mechanisms. Cardiovascular magnetic resonance (CMR) provides insight into pathophysiological mechanisms underlying cardiovascular disease and 31-phosphorus CMR spectroscopy (31P-CMRS) allows non-invasive assessment of the myocardial energetic state. The main aim of the study was to assess whether long COVID-19 syndrome is associated with abnormalities of myocardial structure, function, perfusion and energy metabolism. Prospective case–control study. A total of 20 patients with a clinical diagnosis of long COVID-19 syndrome (seropositive) and no prior underlying cardiovascular disease (CVD) and 10 matching healthy controls underwent 31P-CMRS and CMR at 3T at a single time point. All patients had been symptomatic with acute COVID-19, but none required hospital admission. Between the long COVID-19 syndrome patients and matched contemporary healthy controls there were no differences in myocardial energetics (phosphocreatine to ATP ratio), in cardiac structure (biventricular volumes), function (biventricular ejection fractions, global longitudinal strain), tissue characterization (T1 mapping and late gadolinium enhancement) or perfusion (myocardial rest and stress blood flow, myocardial perfusion reserve). One patient with long COVID-19 syndrome showed subepicardial hyperenhancement on late gadolinium enhancement imaging compatible with prior myocarditis, but no accompanying abnormality in cardiac size, function, perfusion, extracellular volume fraction, native T1, T2 or cardiac energetics. In this prospective case–control study, the overwhelming majority of patients with a clinical long COVID-19 syndrome with no prior CVD did not exhibit any abnormalities in myocardial energetics, structure, function, blood flow or tissue characteristics.
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影响因子：
5.4
作者：
Swoboda PP;McDiarmid AK;Erhayiem B;Ripley DP;Dobson LE;Garg P;Musa TA;Witte KK;Kearney MT;Barth JH;Ajjan R;Greenwood JP;Plein S
通讯作者：
Plein S
DOI：
10.1016/j.ahjo.2021.100025
发表时间：
2021-05
期刊：
American heart journal plus : cardiology research and practice
影响因子：
--
作者：
Dixit NM;Churchill A;Nsair A;Hsu JJ
通讯作者：
Hsu JJ
DOI：
10.1016/j.jcmg.2021.04.011
发表时间：
2021-11
期刊：
JACC. Cardiovascular imaging
影响因子：
--
作者：
Joy G;Artico J;Kurdi H;Seraphim A;Lau C;Thornton GD;Oliveira MF;Adam RD;Aziminia N;Menacho K;Chacko L;Brown JT;Patel RK;Shiwani H;Bhuva A;Augusto JB;Andiapen M;McKnight A;Noursadeghi M;Pierce I;Evain T;Captur G;Davies RH;Greenwood JP;Fontana M;Kellman P;Schelbert EB;Treibel TA;Manisty C;Moon JC;COVIDsortium Investigators
通讯作者：
COVIDsortium Investigators
影响因子：
39.3
作者：
Rider, Oliver J.;Lewandowski, Adam;Neubauer, Stefan
通讯作者：
Neubauer, Stefan
影响因子：
82.9
作者：
Blomberg B;Mohn KG;Brokstad KA;Zhou F;Linchausen DW;Hansen BA;Lartey S;Onyango TB;Kuwelker K;Sævik M;Bartsch H;Tøndel C;Kittang BR;Bergen COVID-19 Research Group;Cox RJ;Langeland N
通讯作者：
Langeland N