Rapid high-resolution three-dimensional mapping of T1 and age-dependent variations in the non-human primate brain using magnetization-prepared rapid gradient-echo (MPRAGE) sequence.
Rapid high-resolution three-dimensional mapping of T1 and age-dependent variations in the non-human primate brain using magnetization-prepared rapid gradient-echo (MPRAGE) sequence.
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DOI：
10.1016/j.neuroimage.2011.02.075
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Silva, Afonso C.
中科院分区：
文献类型：
--
作者：
Liu, Junjie V.;Bock, Nicholas A.;Silva, Afonso C.
在神经科学和神经病学中使用定量T1映射引起了人们对开发T1映射技术的强烈兴趣，该技术可以在短成像和计算时间内以高准确度和精度测量整个大脑中的T1。在这里，我们提出了一种新的反转恢复（IR）的T1映射方法，使用标准的3D磁化准备的快速梯度回波（MPHRR）序列。通过仅改变反转时间（TI），但保持其他参数恒定，MPT图像信号变为与exp（-TI/T1）成线性，从而允许在不进行翻转角校正的情况下进行准确的T1估计。我们还表明，在3个TI采集数据，优化三个不同的TI值，每单位时间提供最大的T1精度，允许新的有效方法来测量和计算T1。我们演示了使用我们的方法在7特斯拉获得3D T1地图的整个大脑在普通绒猴在0.60毫米的分辨率和11分钟内。来自相同个体的T1图谱在不同日期具有高度可重复性。在所有受试者中，大脑灰质T1分布的峰值为1735±52 ms，大脑白色物质T1分布的下缘为1270±43 ms。我们发现，在14年的时间跨度内，随着年龄的增长，绒猴大脑灰质和白色物质的T1均显著降低，这与先前的人类研究一致。该应用表明，基于MPRAGE的3D T1标测快速、准确、精确，可以促进神经科学和神经疾病的高分辨率解剖研究。
The use of quantitative T1 mapping in neuroscience and neurology has raised strong interest in the development of T1-mapping techniques that can measure T1 in the whole brain, with high accuracy and precision and within short imaging and computation times. Here, we present a new inversion-recovery (IR) based T1-mapping method using a standard 3D magnetization-prepared rapid gradient-echo (MPRAGE) sequence. By varying only the inversion time (TI), but keeping other parameters constant, MPRAGE image signals become linear to exp(−TI/T1), allowing for accurate T1 estimation without flip angle correction. We also show that acquiring data at just 3 TIs, with the three different TI values optimized, gives maximum T1 precision per unit time, allowing for new efficient approaches to measure and compute T1. We demonstrate the use of our method at 7 Tesla to obtain 3D T1 maps of the whole brain in common marmosets at 0.60 mm resolution and within 11 minutes. T1 maps from the same individuals were highly reproducible across different days. Across subjects, the peak of cerebral gray matter T1 distribution was 1735±52 ms, and the lower edge of cerebral white matter T1 distribution was 1270±43 ms. We found a significant decrease of T1 in both gray and white matter of the marmoset brain with age over a span of 14 years, in agreement with previous human studies. This application illustrates that MPRAGE-based 3D T1 mapping is rapid, accurate and precise, and can facilitate high-resolution anatomical studies in neuroscience and neurological diseases.
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影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
2.5
作者：
Haselgrove, J;Hunte, M;Steen, RG
通讯作者：
Steen, RG
影响因子：
3.3
作者：
MUGLER, JP;EPSTEIN, FH;BROOKEMAN, JR
通讯作者：
BROOKEMAN, JR
影响因子：
5.7
作者：
Marques, Jose P.;Kober, Tobias;Gruetter, Rolf
通讯作者：
Gruetter, Rolf
影响因子：
3.3
作者：
Shin, Wanyong;Gu, Hong;Yang, Yihong
通讯作者：
Yang, Yihong