An increase in vascular endothelial growth factor (VEGF) and VEGF soluble receptor-1 (sFlt-1) are associated with early recurrent spontaneous abortion.
An increase in vascular endothelial growth factor (VEGF) and VEGF soluble receptor-1 (sFlt-1) are associated with early recurrent spontaneous abortion.
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血管内皮生长因子 (VEGF) 和 VEGF 可溶性受体 1 (sFlt-1) 的增加与早期复发性自然流产相关
DOI：
10.1371/journal.pone.0075759
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chen ZJ
中科院分区：
文献类型：
--
作者：
Pang L;Wei Z;Li O;Huang R;Qin J;Chen H;Fan X;Chen ZJ
复发性自然流产（RSA）是一种影响约1%至5%育龄妇女的健康问题。然而，在大约一半的患者中，RSA的机制尚不清楚。近年来的研究表明胎盘缺血缺氧和内皮功能障碍是导致流产的重要因素。其他研究表明，可溶性FMS样酪氨酸激酶-1（sFlt 1）的水平和表达在缺氧环境下增加。然而，最近有人提出，在前三个月期间母体循环中sFlt-1的降低可作为识别妊娠丢失风险的潜在标志物。在这项前瞻性研究中，在胎儿死亡后短时间内获得临床样本，评估sFlt 1的蛋白表达和母体血清水平，并与正常妊娠的样本进行比较。我们的结果表明，与未怀孕的妇女相比，VEGF和sFlt-1的水平在早期怀孕期间在妇女中均增加（p<0.05），表明VEGF和sFlt-1均与怀孕相关。更重要的是，我们检测到与对照组相比，在随后流产的RSA患者中sFlt 1和VEGF水平和表达显著增加（p<0.05）。这些结果表明VEGF、sFlt-1和RSA之间可能存在相关性，提示sFlt-1和VEGF的高水平和过表达可能与RSA的发病机制有关。
Recurrent spontaneous abortion (RSA) is a health problem that affects approximately 1% to 5% reproductive age woman. Yet, in around half of these patients, the mechanism for RSA is unexplained. Recent studies have indicated that placental ischemia/hypoxia and endothelial dysfunction are important factors in miscarriage. Other studies have indicated that the level and expression of soluble FMS-like tyrosine kinase-1 (sFlt1) is increased under a hypoxic environment. However, decreased sFlt-1 in the maternal circulation during the first trimester has recently been proposed as a potential marker for identifying risk of pregnancy loss. In this prospective study clinical samples were obtained within a short time after the fetal death, protein expression and maternal serum levels of sFlt1 were assessed and compared to samples taken from those with normal pregnancies. Our results indicate that levels of VEGF and sFlt-1 are both increased in women during early pregnancy compared women that are not pregnant (p<0.05) indicating that VEGF and sFlt-1 are both associated with pregnancy. More importantly, we detected a significant (p<0.05) increase in sFlt1 and VEGF levels and expression in the RSA patients who suffered subsequent miscarriages compare to controls. These results demonstrate that there is likely a relationship between VEGF, sFlt-1 and RSA suggesting that the high levels and over expression of sFlt-1 and VEGF might be associated with the pathogenesis of RSA.
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