Complement and humoral immunity.
Complement and humoral immunity.
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DOI：
10.1016/j.vaccine.2008.11.022
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发表时间：
2008-12-30
期刊：
影响因子：
5.5
通讯作者：
Carroll MC
中科院分区：
文献类型：
--
作者：
Carroll MC
补体系统在近一个世纪前被发现，是抗体依赖的杀灭微生物的重要效应器。自早期以来，人们对补体蛋白的生物化学和结构以及它们在调节炎症中的功能有了很多了解。最近，补体在先天免疫和获得性免疫之间的联系中起到了突出的作用。在这篇综述中，我将讨论我们目前对补体在增强对模式抗原和病原体的体液免疫反应中的重要性的理解。如下文所述，补体系统显然参与了“外来”病原体的标记，并以一种既能增强抗体产生又能增强长期记忆的方式将它们“呈现”给B细胞。在本期《疫苗》特刊中，我们看到了补体如何在对细菌和病毒病原体的免疫反应中起关键作用的例子。此外，大多数生物都有共同进化的蛋白质来逃避补体检测，这一发现突显了补体在宿主保护中的重要性。
The complement system was discovered almost a century ago as an important effector in antibody-dependent killing of microorganisms. Since this early period much was learned about the biochemistry and structure of complement proteins and their function in mediating inflammation. More recently, a prominent role for complement was identified in linkage of innate and adaptive immunity. In this review, I will discuss our current understanding of the importance of complement in enhancing the humoral immune response to both model antigens and pathogens. As discussed below, it is evident that the complement system participates in marking of “foreign” pathogens and “presenting” them to B cells in a manner that enhances both antibody production and long term memory. In this special issue of Vaccine, we see examples of how complement is critical in the immune response to bacterial and viral pathogens. Moreover, the finding that most organisms have co-evolved proteins to evade complement detection underscores its importance in host protection.
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DOI：
10.1084/jem.175.2.537
发表时间：
1992-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Finco O;Li S;Cuccia M;Rosen FS;Carroll MC
通讯作者：
Carroll MC
DOI：
10.1084/jem.192.10.1425
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gretz JE;Norbury CC;Anderson AO;Proudfoot AE;Shaw S
通讯作者：
Shaw S
影响因子：
32.4
作者：
Haas, KM;Hasegawa, M;Tedder, TF
通讯作者：
Tedder, TF
影响因子：
56.9
作者：
Fearon, DT;Locksley, RM
通讯作者：
Locksley, RM
影响因子：
30.5
作者：
Guinamard, R;Okigaki, M;Ravetch, JV
通讯作者：
Ravetch, JV