T-Lymphocyte Clone Specific for Pancreatic Islet Antigen
T-Lymphocyte Clone Specific for Pancreatic Islet Antigen
复制标题
胰岛抗原特异性 T 淋巴细胞克隆
DOI：
10.2337/diab.37.10.1444
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发表时间：
1988
期刊：
影响因子：
7.7
通讯作者：
K. Lafferty
中科院分区：
文献类型：
--
作者：
K. Haskins;M. Portas;B. Bradley;D. Wegmann;K. Lafferty
A cloned T-lymphocyte line, BDC-2.5, was derived from a nonobese diabetic (NOD) mouse and has been found to exhibit specificity for islet cell antigen in vitro and in vivo. This clone is a CD4+ T-lymphocyte that proliferates and makes lymphokine in response to islet cell antigen- and NOD antigen-presenting cells. In an in vivo transplantation system in which islet grafts were made in the presence or absence of the BDC-2.5 T-lymphocytes, it was found that incorporation of the islet-specific T-lymphocytes into the graft site resulted in complete destruction of the transplanted tissue. Similar grafts made with pituitary tissue were not affected by the T-lymphocyte clone. These results suggest that the islet-specific T-lymphocytes mediate islet destruction in a tissue-specific manner.
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生物育种/伍斯特（BB/W）近交和杂交大鼠中自身免疫性糖尿病的过继转移。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Like,AA;Weringer,EJ;Holdash,A;McGill,P;Atkinson,D;Rossini,AA
通讯作者：
Rossini,AA
DOI：
10.1056/nejm198605223142106
发表时间：
1986-05
期刊：
The New England Journal of Medicine
影响因子：
--
作者：
G. Eisenbarth
通讯作者：
G. Eisenbarth
影响因子：
29.7
作者：
A. Rossini;J. Mordes;A. Like
通讯作者：
A. Rossini;J. Mordes;A. Like
影响因子：
4.4
作者：
B. J. Miller;M. Appel;J. O'neil;L. Wicker
通讯作者：
B. J. Miller;M. Appel;J. O'neil;L. Wicker
用同种异体鼠胰岛进行体内启动后，胰岛细胞的体外淋巴细胞识别。
DOI：
10.1530/acta.0.1050087
发表时间：
1984
期刊：
Acta endocrinologica
影响因子：
--
作者：
Scott,J;MacKay,PG;Lernmark,A
通讯作者：
Lernmark,A