Odorant reception in the malaria mosquito Anopheles gambiae.
Odorant reception in the malaria mosquito Anopheles gambiae.
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作者：
冈比亚按蚊是撒哈拉以南非洲疟疾的主要传播媒介。它主要通过嗅觉定位人类宿主，但对这一过程的分子基础知之甚少。在这里，我们功能特点冈比亚按蚊气味受体（AgOr）剧目。我们确定了对人类气味成分有强烈反应的受体，这些受体可能在人类识别过程中起作用。其中一些受体的调节范围很窄，一些突出的气味只会引起一个或几个受体的强烈反应，这表明特定的传输通道在人类寻找宿主行为中起着核心作用。冈比亚按蚊受体的分析允许与相应的果蝇气味受体库进行比较。我们发现，气味的差异编码的方式与他们的生态需要的两个物种。我们的分析冈比亚按蚊剧目识别受体，可能是有用的目标，控制疟疾的传播。
The mosquito Anopheles gambiae is the major vector of malaria in sub-Saharan Africa. It locates its human hosts primarily through olfaction, but little is known about the molecular basis of this process. Here we functionally characterize the Anopheles gambiae Odourant Receptor (AgOr) repertoire. We identify receptors that respond strongly to components of human odour and that may act in the process of human recognition. Some of these receptors are narrowly tuned, and some salient odourants elicit strong responses from only one or a few receptors, suggesting a central role for specific transmission channels in human host-seeking behavior. This analysis of the Anopheles gambiae receptors permits a comparison with the corresponding Drosophila melanogaster odourant receptor repertoire. We find that odourants are differentially encoded by the two species in ways consistent with their ecological needs. Our analysis of the Anopheles gambiae repertoire identifies receptors that may be useful targets for controlling the transmission of malaria.
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DOI：
10.2987/8756-971x(2005)21
发表时间：
2005-09-01
影响因子：
1
作者：
Grieco, JP;Achee, NL;Andre, RG
通讯作者：
Andre, RG
影响因子：
16.2
作者：
Dobritsa, AA;van der Goes van Naters, W;Carlson, JR
通讯作者：
Carlson, JR
影响因子：
48
作者：
Haddad, Rafi;Khan, Rehan;Sobel, Noam
通讯作者：
Sobel, Noam
影响因子：
64.5
作者：
Malnic, B;Hirono, J;Buck, LB
通讯作者：
Buck, LB
影响因子：
9.2
作者：
Lu, Tan;Qiu, Yu Tong;Zwiebell, Laurence J.
通讯作者：
Zwiebell, Laurence J.