Transformation of an early-established motor circuit during maturation in zebrafish.
Transformation of an early-established motor circuit during maturation in zebrafish.
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DOI：
10.1016/j.celrep.2022.110654
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发表时间：
2022-04-12
期刊：
影响因子：
8.8
通讯作者：
El Manira, Abdeljabbar
中科院分区：
文献类型：
--
作者：
Pallucchi, Irene;Bertuzzi, Maria;Michel, Jennifer Carlisle;Miller, Adam C.;El Manira, Abdeljabbar
运动是由脊髓回路介导的，脊髓回路产生具有精确协调和活力的运动。这些电路的组装在发育早期就被定义了;然而，它们的组织和功能在整个发育过程中是否保持不变还不清楚。在这里，我们表明，第一个建立的快速电路之间的两个背侧位于V2 A中间神经元类型和四个主要运动神经元经历了重大的转变，在成年斑马鱼相比，在幼虫中报道。存在现有连接的丢失和新连接的建立，以及突触传递的模式、可塑性和强度的改变。此外，我们发现，这个电路不再作为一个游泳节奏发生器，而是它的组件成为嵌入在脊髓逃生电路和控制推进后，最初的逃生转。因此，我们的研究结果揭示了动物向成年期发展时，运动回路的组织和功能发生了显着变化。Pallucchi等人揭示了斑马鱼早期建立的运动回路在成熟过程中经历了深刻的重组。存在现有连接的丧失和新连接的建立，结合功能的改变以适应新的行为需求。
Locomotion is mediated by spinal circuits that generate movements with a precise coordination and vigor. The assembly of these circuits is defined early during development; however, whether their organization and function remain invariant throughout development is unclear. Here, we show that the first established fast circuit between two dorsally located V2a interneuron types and the four primary motoneurons undergoes major transformation in adult zebrafish compared with what was reported in larvae. There is a loss of existing connections and establishment of new connections combined with alterations in the mode, plasticity, and strength of synaptic transmission. In addition, we show that this circuit no longer serves as a swim rhythm generator, but instead its components become embedded within the spinal escape circuit and control propulsion following the initial escape turn. Our results thus reveal significant changes in the organization and function of a motor circuit as animals develop toward adulthood. Pallucchi et al. reveal that an early-established motor circuit in zebrafish undergoes a profound reorganization during maturation toward adulthood. There is a loss of existing connections and establishment of new connections combined with a change in function to suit new behavioral demands.
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影响因子：
5.3
作者：
Bucher, D;Prinz, AA;Marder, E
通讯作者：
Marder, E
DOI：
10.1073/pnas.1216256110
发表时间：
2012-12-26
影响因子：
11.1
作者：
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影响因子：
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作者：
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