Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC).
Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC).
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DOI：
10.1007/s11239-013-1042-5
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发表时间：
2014-10
影响因子：
4
通讯作者：
Wakamiya N
中科院分区：
文献类型：
--
作者：
Takahashi K;Ohtani K;Larvie M;Moyo P;Chigweshe L;Van Cott EM;Wakamiya N
肾凝集素1（CL-K1）是最近发现的一种在大多数器官中合成并在血液中循环的凝集素。CL-K1是一种先天性免疫分子，可能在宿主防御中发挥重要作用。由于一些凝集素也在凝血中起作用，我们假设CL-K1的作用在弥散性血管内凝血（DIC）中可能是明显的，弥散性血管内凝血（DIC）是在先天免疫系统的深度激活的情况下发生的凝血系统的严重紊乱。DIC是一种严重的疾病，多器官功能衰竭的发生率高，死亡率高，但没有可靠的生物标志物或危险因素。在本研究中，我们共检测了659例标本的血浆CL-K1浓度，其中包括549例DIC患者，82例非DIC患者和27例健康志愿者。这些队列中的中位血浆CL-K1水平分别为424、238和245 ng/ml，后两组无显著差异。DIC患者血浆CL-K1升高的发生率显著高于非DIC患者，比值比为1.929（置信区间1.041-3.866）。DIC组中感染、肾脏疾病、呼吸道疾病和心脏疾病的发生率高于非DIC组。在DIC组中，血管疾病与血浆CL-K1水平升高相关，而年龄和急性疾病对血浆CL-K1水平几乎没有影响。独立于DIC，血浆CL-K1水平升高与呼吸系统疾病和凝血障碍相关。这些结果表明，特定的疾病可能会影响CL-K1的合成在一个器官依赖性的方式和血浆CL-K1水平升高与DIC的存在。需要对患者队列进行进一步研究。我们认为，血浆CL-K1升高可能是一个新的有用的危险因素和可能的生物标志物，为发展DIC的预测。
Collectin kidney 1 (CL-K1) is a recently identified collectin that is synthesized in most organs and circulates in blood. CL-K1 is an innate immune molecule that may play a significant role in host defense. As some collectins also play a role in coagulation, we hypothesized that an effect of CL-K1 may be apparent in disseminated intravascular coagulation (DIC), a gross derangement of the coagulation system that occurs in the setting of profound activation of the innate immune system. DIC is a grave medical condition with a high incidence of multiple organ failure and high mortality and yet there are no reliable biomarkers or risk factors. In our present study, we measured plasma CL-K1 concentration in a total of 659 specimens, including 549 DIC patients, 82 non-DIC patients and 27 healthy volunteers. The median plasma CL-K1 levels in these cohorts were 424, 238 and 245 ng/ml, respectively, with no significant difference in the latter two groups. The incidence of elevated plasma CL-K1 was significantly higher in the DIC patients compared to the non-DIC patients, resulting in an odds ratio of 1.929 (confidence interval 1.041–3.866). Infection, renal diseases, respiratory diseases, and cardiac diseases were more frequently observed in the DIC group than in the non-DIC group. In the DIC group, vascular diseases were associated with elevated plasma CL-K1 levels while age and acute illness had little effect on plasma CL-K1 levels. Independent of DIC, elevated plasma CL-K1 levels were associated with respiratory disease and coagulation disorders. These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC. Further investigations in cohorts of patients are warranted. We propose that elevated plasma CL-K1 may be a new useful risk factor and possibly biomarker for the prediction of developing DIC.
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影响因子：
3.2
作者：
Motomura, Wataru;Yoshizaki, Takayuki;Wakamiya, Nobutaka
通讯作者：
Wakamiya, Nobutaka
影响因子：
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影响因子：
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影响因子：
11.8
作者：
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