A hippocampo-cerebellar centred network for the learning and execution of sequence-based navigation.
A hippocampo-cerebellar centred network for the learning and execution of sequence-based navigation.
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DOI：
10.1038/s41598-017-18004-7
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发表时间：
2017-12-19
影响因子：
4.6
通讯作者：
Rondi-Reig L
中科院分区：
文献类型：
--
作者：
Babayan BM;Watilliaux A;Viejo G;Paradis AL;Girard B;Rondi-Reig L
我们如何将自我运动转化为目标导向的行动？在这里，我们研究了探索和目标导向行为中自我运动加工的认知结构。这项任务是在一个具有有限和模糊的外部地标的环境中进行的，它限制了老鼠使用基于自我运动的信息进行基于序列的导航。后行为分析结合了基于c-Fos成像和图论分析的脑网络表征以及学习过程的计算建模。研究显示，在探索阶段，一个以大脑皮层和基底神经节为中心的广泛网络，而一个由海马和小脑活动主导的网络似乎维持了基于序列的导航。学习过程可以通过结合过去行为记忆和无模型强化学习的算法来建模，这些参数表明海马和小脑结构在学习中将自我运动转化为一系列目标导向的行动方面发挥了核心作用。
How do we translate self-motion into goal-directed actions? Here we investigate the cognitive architecture underlying self-motion processing during exploration and goal-directed behaviour. The task, performed in an environment with limited and ambiguous external landmarks, constrained mice to use self-motion based information for sequence-based navigation. The post-behavioural analysis combined brain network characterization based on c-Fos imaging and graph theory analysis as well as computational modelling of the learning process. The study revealed a widespread network centred around the cerebral cortex and basal ganglia during the exploration phase, while a network dominated by hippocampal and cerebellar activity appeared to sustain sequence-based navigation. The learning process could be modelled by an algorithm combining memory of past actions and model-free reinforcement learning, which parameters pointed toward a central role of hippocampal and cerebellar structures for learning to translate self-motion into a sequence of goal-directed actions.
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影响因子：
2.9
作者：
Arrigo, Alessandro;Mormina, Enricomaria;Milardi, Demetrio
通讯作者：
Milardi, Demetrio
影响因子：
4.2
作者：
Fouquet, C.;Petit, G. H.;Rondi-Reig, L.
通讯作者：
Rondi-Reig, L.
影响因子：
16.2
作者：
Euston DR;Gruber AJ;McNaughton BL
通讯作者：
McNaughton BL
影响因子：
5.3
作者：
Bellassen, Virginie;Igloi, Kinga;Rondi-Reig, Laure
通讯作者：
Rondi-Reig, Laure
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y