Molecular evolution of umami/sweet taste receptor genes in reptiles.
Molecular evolution of umami/sweet taste receptor genes in reptiles.
复制标题
爬行动物鲜味/甜味受体基因的分子进化
作者：
Feng P;Liang S
感觉系统在动物生存中发挥着重要作用。这些系统的变化可能对于新环境中物种的进化至关重要。先前探索摄食生态与Tas1r进化之间相关性的研究主要集中在哺乳动物和鸟类上，发现这种关系很复杂。然而，在爬行动物中，Tas1r 进化与饮食偏好之间的相关性仍不清楚。在这里，我们试图探索主要爬行动物类群（海龟、蛇、蜥蜴、鳄鱼）的代表性物种中的这种关系，这些爬行动物的基因组信息是已知的。我们首先预测 Tas1r 的功能（完整、部分或有缺陷），然后将其与喂养偏好相关联。结果，我们在 19 种爬行动物中鉴定出 11 个 Tas1r1、12 个 Tas1r2 和 12 个 Tas1r3 基因是部分或完整的，另外 22 个 Tas1r 基因缺失或假化。我们发现，正如在其他一些脊椎动物群体中所揭示的那样，爬行动物的摄食生态与 Tas1r 进化之间不存在相关性：基因组预测表明，Tas1r 基因在蛇中可能已经丢失或假化，但在鳄鱼和睾丸类中，无论其食性如何，Tas1r 基因要么是完整的，要么是部分的。因此，我们认为爬行动物中 Tas1r 进化的驱动力是复杂的，并且某些物种不经咀嚼而吞咽整个食物的摄食习惯或味蕾的缺乏可能是鲜味/甜味感知丧失的原因。此外，我们建议在从公开的基因组数据库预测基因功能时应谨慎。
Sensory systems play an important role in animal survival. Changes to these systems may be critical in evolution of species in new environments. Previous studies exploring the correlation between feeding ecology and Tas1r evolution mainly focused on mammals and birds, and found that the relationship was complex. However, in reptiles, the correlation between Tas1r evolution and dietary preferences is still unclear. Here, we attempted to explore this relationship in representative species of the major groups of reptiles (turtles, snakes, lizards, crocodilians), for which the genome information is known. We first predicted the functionality (intact, partial, or defective) of Tas1r, and then related it to the feeding preferences. As a result, we identified 11 Tas1r1, 12 Tas1r2, and 12 Tas1r3 genes to be partial or intact and another 22 Tas1r genes to be absent or pseudogenized in the 19 reptiles. We found that, as it was revealed in some other vertebrate groups, no correlation existed between feeding ecology and Tas1r evolution in reptiles: genomic prediction indicated that the Tas1r genes possibly have been lost or pseudogenized in snakes, but in crocodylia and testudines Tas1r genes are either intact or partial, regardless of their feeding habits. Thus, we suggest that the driving force of Tas1r evolution in reptiles is complex, and the feeding habit of swallowing food whole without chewing or the absence of taste buds in certain species may account for the possible umami/sweet perception loss. In addition, we propose that caution should be taken when predicting gene functionality from the publicly available genome database.
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软壳乌龟和绿海龟的基因组草案对特定特定身体计划的发展和演变产生了见解。
影响因子：
30.8
作者：
Wang, Zhuo;Pascual-Anaya, Juan;Zadissa, Amonida;Li, Wenqi;Niimura, Yoshihito;Huang, Zhiyong;Li, Chunyi;White, Simon;Xiong, Zhiqiang;Fang, Dongming;Wang, Bo;Ming, Yao;Chen, Yan;Zheng, Yuan;Kuraku, Shigehiro;Pignatelli, Miguel;Herrero, Javier;Beal, Kathryn;Nozawa, Masafumi;Li, Qiye;Wang, Juan;Zhang, Hongyan;Yu, Lili;Shigenobu, Shuji;Wang, Junyi;Liu, Jiannan;Flicek, Paul;Searle, Steve;Wang, Jun;Kuratani, Shigeru;Yin, Ye;Aken, Bronwen;Zhang, Guojie;Irie, Naoki
通讯作者：
Irie, Naoki
DOI：
10.1126/science.1253451
发表时间：
2014-12-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jarvis ED;Mirarab S;Aberer AJ;Li B;Houde P;Li C;Ho SY;Faircloth BC;Nabholz B;Howard JT;Suh A;Weber CC;da Fonseca RR;Li J;Zhang F;Li H;Zhou L;Narula N;Liu L;Ganapathy G;Boussau B;Bayzid MS;Zavidovych V;Subramanian S;Gabaldón T;Capella-Gutiérrez S;Huerta-Cepas J;Rekepalli B;Munch K;Schierup M;Lindow B;Warren WC;Ray D;Green RE;Bruford MW;Zhan X;Dixon A;Li S;Li N;Huang Y;Derryberry EP;Bertelsen MF;Sheldon FH;Brumfield RT;Mello CV;Lovell PV;Wirthlin M;Schneider MP;Prosdocimi F;Samaniego JA;Vargas Velazquez AM;Alfaro-Núñez A;Campos PF;Petersen B;Sicheritz-Ponten T;Pas A;Bailey T;Scofield P;Bunce M;Lambert DM;Zhou Q;Perelman P;Driskell AC;Shapiro B;Xiong Z;Zeng Y;Liu S;Li Z;Liu B;Wu K;Xiao J;Yinqi X;Zheng Q;Zhang Y;Yang H;Wang J;Smeds L;Rheindt FE;Braun M;Fjeldsa J;Orlando L;Barker FK;Jønsson KA;Johnson W;Koepfli KP;O'Brien S;Haussler D;Ryder OA;Rahbek C;Willerslev E;Graves GR;Glenn TC;McCormack J;Burt D;Ellegren H;Alström P;Edwards SV;Stamatakis A;Mindell DP;Cracraft J;Braun EL;Warnow T;Jun W;Gilbert MT;Zhang G
通讯作者：
Zhang G
DOI：
10.1126/science.1254449
发表时间：
2014-12-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Green RE;Braun EL;Armstrong J;Earl D;Nguyen N;Hickey G;Vandewege MW;St John JA;Capella-Gutiérrez S;Castoe TA;Kern C;Fujita MK;Opazo JC;Jurka J;Kojima KK;Caballero J;Hubley RM;Smit AF;Platt RN;Lavoie CA;Ramakodi MP;Finger JW Jr;Suh A;Isberg SR;Miles L;Chong AY;Jaratlerdsiri W;Gongora J;Moran C;Iriarte A;McCormack J;Burgess SC;Edwards SV;Lyons E;Williams C;Breen M;Howard JT;Gresham CR;Peterson DG;Schmitz J;Pollock DD;Haussler D;Triplett EW;Zhang G;Irie N;Jarvis ED;Brochu CA;Schmidt CJ;McCarthy FM;Faircloth BC;Hoffmann FG;Glenn TC;Gabaldón T;Paten B;Ray DA
通讯作者：
Ray DA
影响因子：
2.6
作者：
Ishimaru, Y;Okada, S;Abe, K
通讯作者：
Abe, K
影响因子：
--
作者：
Feng Ping;Zhao HuaBin
通讯作者：
Zhao HuaBin