Sex differences in the regulation of social and anxiety-related behaviors: insights from vasopressin and oxytocin brain systems.
Sex differences in the regulation of social and anxiety-related behaviors: insights from vasopressin and oxytocin brain systems.
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DOI：
10.1016/j.conb.2018.02.011
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发表时间：
2018-04
影响因子：
5.7
通讯作者：
Veenema AH
中科院分区：
文献类型：
--
作者：
Bredewold R;Veenema AH
为了理解大脑如何调节行为，必须考虑许多变量，其中性别是一个突出的变量。在这篇综述中，我们将讨论最近的人类和啮齿动物的研究表明，性别特异性参与的神经肽加压素和催产素的社会和焦虑相关的行为。我们讨论，性别差异可以在青春期前的年龄是明显的，如在青少年大鼠的加压素系统的社会识别，社会游戏，和焦虑的性别特异性调节。我们进一步讨论了人类和啮齿动物的催产素系统以性别特异性的方式改变大脑激活、焦虑和社会性动机。最后，我们建议，加压素和催产素介导的性别特异性的大脑机制的知识可以提供重要的见解，这些神经肽系统如何有助于性别特异性的脆弱性，以及对扰动的恢复力，随后与社会和情绪障碍。
To understand how the brain regulates behavior, many variables must be taken into account, with sex as a prominent variable. In this review, we will discuss recent human and rodent studies showing the sex-specific involvement of the neuropeptides vasopressin and oxytocin in social and anxiety-related behaviors. We discuss that sex differences can be evident at pre-pubertal ages as seen in the sex-specific regulation of social recognition, social play, and anxiety by the vasopressin system in juvenile rats. We further discuss that the oxytocin system in humans and rodents alters brain activation, anxiety, and sociosexual motivation in sex-specific ways. Finally, we propose that knowledge of vasopressin and oxytocin mediated sex-specific brain mechanisms can provide essential insights into how these neuropeptide systems contribute to sex-specific vulnerability as well as resilience to perturbations, with subsequent relevance to social and emotional disorders.
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