Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women.
Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women.
复制标题
DOI：
10.1016/j.yhbeh.2014.12.009
复制
发表时间：
2015-03
影响因子：
3.5
通讯作者：
Heiman JR
中科院分区：
文献类型：
--
作者：
Gregory R;Cheng H;Rupp HA;Sengelaub DR;Heiman JR
生完孩子后，女性的性欲通常会下降，对婴儿刺激的反应会增加。这些产后变化可能被视为生殖利益的权衡，这可能是由于大脑活动的改变，包括与奖励相关的区域。本研究的目的是描述催产素和parity在生殖刺激，特别是婴儿和性图像的反应中对奖励区域激活的作用。由于腹侧被盖区（VTA）和伏隔核（NAc）已被证明与奖励有关，因此它们被视为预期活动变化的区域。催产素被选为生殖权衡的潜在中介，因为它与母婴互动（包括母乳喂养和结合）和性反应都有关系。我们预测，产后妇女对婴儿刺激表现出更高的奖励区激活，未生育妇女对性刺激表现出更高的激活，催产素会增加未生育妇女对婴儿刺激的激活。为了验证这一点，我们使用功能磁共振成像测量了29名产后妇女和30名未分娩妇女对婴儿照片、性照片和中性照片的反应，测量了VTA和NAc的激活。参与者完成了性抑制（SIS）和性兴奋（SES）量表以及女性性功能简要指数（BISF-W），其中包括性欲维度，在观看功能性磁共振成像扫描仪中哭泣和微笑的婴儿图像和性图像之前，他们接受了催产素或安慰剂鼻腔喷雾剂。对于两组女性来说，鼻内注射催产素增加了哭泣婴儿和性图像的VTA激活，但没有增加微笑婴儿的图像。我们发现，与未产妇女相比，产后妇女表现出较低的SES，较高的SIS和较低的性欲。在对等组中，SES得分与VTA激活和对性图像的主观唤醒评级相关。在产后女性中，性欲与VTA对性图像的激活和SES呈正相关。我们的研究结果表明，产后性欲下降可能部分是由VTA激活介导的，催产素在性刺激和婴儿刺激下增加了VTA的激活，而不是NAc。催产素可能通过增加VTA对婴儿显著刺激的激活来改变产后妇女的生殖优先级。
After giving birth, women typically experience decreased sexual desire and increased responsiveness to infant stimuli. These postpartum changes may be viewed as a trade-off in reproductive interests, which could be due to alterations in brain activity including areas associated with reward. The goal of this study was to describe the roles of oxytocin and parity on reward area activation in response to reproductive stimuli, specifically infant and sexual images. Because they have been shown to be associated with reward, the ventral tegmental area (VTA) and nucleus accumbens (NAc) were targeted as areas of expected alterations in activity. Oxytocin was chosen as a potential mediator of reproductive trade-offs because of its relationship to both mother–infant interactions, including breastfeeding and bonding, and sexual responses. We predicted that postpartum women would show higher reward area activation to infant stimuli and nulliparous women would show higher activation to sexual stimuli and that oxytocin would increase activation to infant stimuli in nulliparous women. To test this, we measured VTA and NAc activation using fMRI in response to infant photos, sexual photos, and neutral photos in 29 postpartum and 30 nulliparous women. Participants completed the Sexual Inhibition (SIS) and Sexual Excitation (SES) Scales and the Brief Index of Sexual Function for Women (BISF-W), which includes a sexual desire dimension, and received either oxytocin or placebo nasal spray before viewing crying and smiling infant and sexual images in an fMRI scanner. For both groups of women, intranasal oxytocin administration increased VTA activation to both crying infant and sexual images but not to smiling infant images. We found that postpartum women showed lower SES, higher SIS, and lower sexual desire compared to nulliparous women. Across parity groups, SES scores were correlated with VTA activation and subjective arousal ratings to sexual images. In postpartum women, sexual desire was positively correlated with VTA activation to sexual images and with SES. Our findings show that postpartum decreases in sexual desire may in part be mediated by VTA activation, and oxytocin increased activation of the VTA but not NAc in response to sexual and infant stimuli. Oxytocin may contribute to the altered reproductive priorities in postpartum women by increasing VTA activation to salient infant stimuli.
登录
查看更多内容
影响因子：
4.7
作者：
Carlezon WA Jr;Thomas MJ
通讯作者：
Thomas MJ
影响因子：
4.7
作者：
Gordon, Ilanit;Martin, Carina;Feldman, Ruth;Leckman, James F.
通讯作者：
Leckman, James F.
影响因子：
3.6
作者：
De Judicibus, MA;McCabe, MP
通讯作者：
McCabe, MP
影响因子：
7.2
作者：
Botros, Sylvia M.;Abramov, Yoram;Goldberg, Roger P.
通讯作者：
Goldberg, Roger P.
DOI：
10.1196/annals.1384.006
发表时间：
2007-01-01
期刊：
ORAL-BASED DIAGNOSTICS
影响因子：
--
作者：
Carter, C. Sue;Pournajafi-Nazarloo, Hossein;Schwertz, Dorie
通讯作者：
Schwertz, Dorie