Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study.
Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study.
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DOI：
10.1373/clinchem.2012.192153
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发表时间：
2012-12
影响因子：
9.3
通讯作者：
Januzzi JL
中科院分区：
文献类型：
--
作者：
Coglianese EE;Larson MG;Vasan RS;Ho JE;Ghorbani A;McCabe EL;Cheng S;Fradley MG;Kretschman D;Gao W;O'Connor G;Wang TJ;Januzzi JL
可溶性 ST2 (sST2) 是一种心脏生物标志物，其浓度随心肌应变而升高。 sST2 浓度升高可以预测心力衰竭和心肌梗死患者的不良后果。由于 sST2 在流动个体中的第一代检测基本上无法检测到，因此关于其在社区人群中的分布和相关性的数据很少。我们使用高灵敏度 ELISA 对参加常规检查的 3450 名弗雷明汉心脏研究参与者测量了 sST2。我们使用多变量线性回归模型来识别一般样本中与 sST2 相关的协变量。我们通过排除患有流行性冠心病、心力衰竭、心房颤动、糖尿病、高血压、肥胖、瓣膜病、左心室收缩功能障碍以及肺肾功能障碍的个体来获得参考样本（n = 1136）。我们使用经验和分位数回归技术来估计第 2.5、50、97.5 和 99 分位数。在一般样本中（平均年龄 59 岁，55% 为女性），收缩压 (P = 0.006)、抗高血压药物的使用 (P = 0.03) 和糖尿病 (P < 0.001) 与 sST2 浓度相关。在参考样本中（平均年龄 55 岁，59% 为女性），男性 (P < 0.0001) 和年龄较大 (P = 0.004) 预示着较高的 sST2 浓度。使用分位数和经验方法来定义参考区间。使用经验方法，不同年龄组的 99% 百分位数上限范围为男性 46.6 至 64.4 μg/L，女性 36.7 至 53.0 μg/L。在一个特征明确、基于社区的队列中，男性和女性的 sST2 值不同，随着年龄的增长而增加，并且与糖尿病和高血压相关。
Soluble ST2 (sST2) is a cardiac biomarker whose concentration rises in response to myocardial strain. Increased sST2 concentrations may predict adverse outcomes in patients with heart failure and myocardial infarction. Because sST2 was largely undetectable with first-generation assays in ambulatory individuals, there are few data regarding its distribution and correlates in community-based populations. We measured sST2 using a highly sensitive ELISA in 3450 Framingham Heart Study participants who attended a routine examination. We used multivariable linear regression models to identify covariates associated with sST2 in the general sample. We obtained a reference sample (n = 1136) by excluding individuals with prevalent coronary disease, heart failure, atrial fibrillation, diabetes, hypertension, obesity, valvular disease, left ventricular systolic dysfunction, and pulmonary and renal dysfunction. We used empiric and quantile regression techniques to estimate the 2.5th, 50th, 97.5th, and 99th quantiles. In the general sample (mean age 59 years, 55% women), systolic blood pressure (P = 0.006), antihypertensive medication use (P = 0.03), and diabetes (P < 0.001) were associated with sST2 concentrations. In the reference sample (mean age 55, 59% women), male sex (P < 0.0001) and older age (P = 0.004) were predictive of higher sST2 concentrations. Quantile and empirical methods were used to define the reference intervals. Using the empirical approach, upper 99% percentile values in different age groups ranged from 46.6 to 64.4 μg/L in men and 36.7 to 53.0 μg/L in women. In a well-characterized, community-based cohort, values for sST2 differ between men and women, increase with age, and are associated with diabetes and hypertension.
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影响因子：
6
作者：
Boisot, Saskia;Beede, Jennifer;Fitzgerald, Robert L.
通讯作者：
Fitzgerald, Robert L.
影响因子：
37.8
作者：
Wang TJ;Wollert KC;Larson MG;Coglianese E;McCabe EL;Cheng S;Ho JE;Fradley MG;Ghorbani A;Xanthakis V;Kempf T;Benjamin EJ;Levy D;Vasan RS;Januzzi JL
通讯作者：
Januzzi JL
影响因子：
38.9
作者：
Brunner, M;Krenn, C;Ankersmit, HJ
通讯作者：
Ankersmit, HJ
影响因子：
7.7
作者：
Ingelsson, Erik;Sullivan, Lisa M.;Vasan, Ramachandran S.
通讯作者：
Vasan, Ramachandran S.
DOI：
10.1164/ajrccm.164.2.2008120
发表时间：
2001-07-15
影响因子：
24.7
作者：
Oshikawa, K;Kuroiwa, K;Sugiyama, Y
通讯作者：
Sugiyama, Y