Developmental methamphetamine exposure results in short- and long-term alterations in hypothalamic-pituitary-adrenal-axis-associated proteins.
Developmental methamphetamine exposure results in short- and long-term alterations in hypothalamic-pituitary-adrenal-axis-associated proteins.
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发育的甲基苯丙胺暴露会导致下丘脑 - 垂体 - 肾上腺轴相关蛋白的短期和长期改变。
DOI：
10.1159/000351278
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发表时间：
2013
影响因子：
2.9
通讯作者：
Raber J
中科院分区：
文献类型：
--
作者：
Zuloaga DG;Siegel JA;Acevedo SF;Agam M;Raber J
甲基苯丙胺（MA）的发育暴露会导致长期的行为和认知缺陷。MA可能诱导这些缺陷的一个途径是通过升高糖皮质激素水平。大脑发育过程中糖皮质激素过度分泌可导致下丘脑-垂体-肾上腺（HPA）轴长期中断。这些干扰影响调节的压力反应，并可能有助于行为和认知缺陷报告后，发展MA曝光。此外，与HPA轴相关的蛋白质（包括加压素、催产素和糖皮质激素受体（GR））的改变与情绪和认知障碍相关。因此，我们假设早期MA暴露将导致HPA轴相关蛋白表达的短期和长期改变。雄性小鼠从出生后第11-20天（P）用MA（每日5 mg/kg）或生理盐水处理。在P20和P90，小鼠进行灌注，并处理其大脑内HPA轴相关区域的加压素，催产素和GR免疫反应性。在P20，有一个显着减少的加压素免疫反应细胞的数量和面积所占的加压素免疫反应在室旁核（PVN）的MA处理的小鼠，但没有差异催产素免疫反应在PVN，或GR免疫反应在海马或PVN。在杏仁核中央，GR免疫反应所占面积减少MA。在P90，加压素免疫反应细胞的数量仍然减少，但所占面积的加压素免疫反应不再不同于生理盐水对照。MA对P90时催产素或GR免疫反应性无影响。因此，发展MA曝光有短期和长期的影响，加压素免疫反应性和GR免疫反应性的短期影响。
Developmental exposure to methamphetamine (MA) causes long-term behavioral and cognitive deficits. One pathway through which MA might induce these deficits is by elevating glucocorticoid levels. Glucocorticoid overexposure during brain development can lead to long-term disruptions in the hypothalamic-pituitary-adrenal (HPA) axis. These disruptions affect the regulation of stress responses and may contribute to behavioral and cognitive deficits reported following developmental MA exposure. Furthermore, alterations in proteins associated with the HPA axis, including vasopressin, oxytocin, and glucocorticoid receptors (GR), are correlated with disruptions in mood and cognition. We therefore hypothesized that early MA exposure will result in short- and long-term alterations in the expression of HPA axis-associated proteins. Male mice were treated with MA (5 mg/kg daily) or Saline from postnatal day (P) 11–20. At P20 and P90, mice were perfused and their brains processed for vasopressin, oxytocin, and GR-immunoreactivity within HPA axis-associated regions. At P20, there was a significant decrease in the number of vasopressin-immunoreactive cells and area occupied by vasopressin-immunoreactiviy in the paraventricular nucleus (PVN) of MA-treated mice, but no difference in oxytocin-immunoreactivity in the PVN, or GR-immunoreactivity in the hippocampus or PVN. In the central nucleus of the amygdala, area occupied by GR-immunoreactivity was decreased by MA. At P90, the number of vasopressin-immunoreactive cells was still decreased, but the area occupied by vasopressin-immunoreactivity no longer differed from Saline controls. No effects of MA were found on oxytocin or GR-immunoreactivity at P90. Thus developmental MA exposure has short- and long-term effects on vasopressin-immunoreactivity and short-term effects on GR-immunoreactivity.
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影响因子：
2.9
作者：
Dean, F;Matthews, SG
通讯作者：
Matthews, SG
DOI：
10.1016/s0169-328x(01)00184-x
发表时间：
2001-09-10
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Deng, XL;Wang, Y;Cadet, JL
通讯作者：
Cadet, JL
DOI：
10.1016/s0169-328x(03)00257-2
发表时间：
2003-09-10
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Kabbaj, M;Yoshida, S;Sato, M
通讯作者：
Sato, M
DOI：
10.1152/ajpregu.2000.279.5.r1899
发表时间：
2000-11-01
影响因子：
2.8
作者：
Brabham, T;Phelka, A;Vázquez, DM
通讯作者：
Vázquez, DM
影响因子：
3.5
作者：
Egashira, Nobuaki;Mishima, Kenichi;Fujiwara, Michihiro
通讯作者：
Fujiwara, Michihiro