Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.
Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder.
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作者：
双相情感障碍（BD）是一种复杂的动态疾病，通常在青春期后期或成年早期发病，随后是一个间歇性过程，其间有阈下症状或心境正常。它是复杂的积累共病的医疗和精神疾病。BD的病因仍然未知，也没有可靠的生物学标志物被确定。这可能是由于缺乏全面的本体论框架，最重要的是，大多数研究都是基于小的非代表性临床样本和横断面设计。我们建议建立一个大的，全球性的BD纵向队列，以多维度和多学科的方式进行一致的研究，以确定病因，并帮助改善治疗。在此，我们建议收集广泛的数据，反映BD的异源表型表现，包括情绪、神经认知、个性、行为、睡眠和昼夜节律、生活故事和结果领域的维度和类别测量。结合遗传和生物信息，这种方法促进了当前本体系统内和跨本体系统的数据的整合和协调，同时支持范式转变，这将促进发现并成为新假设的基础。
Bipolar disorder (BD) is a complex and dynamic condition with a typical onset in late adolescence or early adulthood followed by an episodic course with intervening periods of subthreshold symptoms or euthymia. It is complicated by the accumulation of comorbid medical and psychiatric disorders. The etiology of BD remains unknown and no reliable biological markers have yet been identified. This is likely due to lack of comprehensive ontological framework and, most importantly, the fact that most studies have been based on small nonrepresentative clinical samples with cross‐sectional designs. We propose to establish large, global longitudinal cohorts of BD studied consistently in a multidimensional and multidisciplinary manner to determine etiology and help improve treatment. Herein we propose collection of a broad range of data that reflect the heterogenic phenotypic manifestations of BD that include dimensional and categorical measures of mood, neurocognitive, personality, behavior, sleep and circadian, life‐story, and outcomes domains. In combination with genetic and biological information such an approach promotes the integrating and harmonizing of data within and across current ontology systems while supporting a paradigm shift that will facilitate discovery and become the basis for novel hypotheses.
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影响因子：
4.8
作者：
Ching CRK;Hibar DP;Gurholt TP;Nunes A;Thomopoulos SI;Abé C;Agartz I;Brouwer RM;Cannon DM;de Zwarte SMC;Eyler LT;Favre P;Hajek T;Haukvik UK;Houenou J;Landén M;Lett TA;McDonald C;Nabulsi L;Patel Y;Pauling ME;Paus T;Radua J;Soeiro-de-Souza MG;Tronchin G;van Haren NEM;Vieta E;Walter H;Zeng LL;Alda M;Almeida J;Alnaes D;Alonso-Lana S;Altimus C;Bauer M;Baune BT;Bearden CE;Bellani M;Benedetti F;Berk M;Bilderbeck AC;Blumberg HP;Bøen E;Bollettini I;Del Mar Bonnin C;Brambilla P;Canales-Rodríguez EJ;Caseras X;Dandash O;Dannlowski U;Delvecchio G;Díaz-Zuluaga AM;Dima D;Duchesnay É;Elvsåshagen T;Fears SC;Frangou S;Fullerton JM;Glahn DC;Goikolea JM;Green MJ;Grotegerd D;Gruber O;Haarman BCM;Henry C;Howells FM;Ives-Deliperi V;Jansen A;Kircher TTJ;Knöchel C;Kramer B;Lafer B;López-Jaramillo C;Machado-Vieira R;MacIntosh BJ;Melloni EMT;Mitchell PB;Nenadic I;Nery F;Nugent AC;Oertel V;Ophoff RA;Ota M;Overs BJ;Pham DL;Phillips ML;Pineda-Zapata JA;Poletti S;Polosan M;Pomarol-Clotet E;Pouchon A;Quidé Y;Rive MM;Roberts G;Ruhe HG;Salvador R;Sarró S;Satterthwaite TD;Schene AH;Sim K;Soares JC;Stäblein M;Stein DJ;Tamnes CK;Thomaidis GV;Upegui CV;Veltman DJ;Wessa M;Westlye LT;Whalley HC;Wolf DH;Wu MJ;Yatham LN;Zarate CA;Thompson PM;Andreassen OA;ENIGMA Bipolar Disorder Working Group
通讯作者：
ENIGMA Bipolar Disorder Working Group
影响因子：
6.9
作者：
Burdick KE;Russo M;Frangou S;Mahon K;Braga RJ;Shanahan M;Malhotra AK
通讯作者：
Malhotra AK
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
DOI：
10.1007/978-3-319-49959-8_11
发表时间：
2017-01-01
期刊：
COMPUTATIONAL NEUROLOGY AND PSYCHIATRY
影响因子：
--
作者：
Cochran, Amy L.;Schultz, Andre;Forger, Daniel B.
通讯作者：
Forger, Daniel B.