Epigenetics, oestradiol and hippocampal memory consolidation.
Epigenetics, oestradiol and hippocampal memory consolidation.
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DOI：
10.1111/jne.12106
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发表时间：
2013-11
影响因子：
3.2
通讯作者：
Frick KM
中科院分区：
文献类型：
--
作者：
Frick KM
组蛋白和DNA的表观遗传改变对海马突触可塑性和认知功能至关重要，并有助于精神疾病和神经退行性疾病的病因学。海马记忆的形成依赖于组蛋白的改变和DNA甲基化，越来越多的证据表明，这些表观遗传过程的调节因素，如环境丰富，压力和激素的调节，大大影响记忆功能。我们实验室最近的工作表明，性类固醇激素17β-雌二醇（E2）增强年轻成年雌性小鼠新物体识别记忆巩固的能力依赖于背侧海马中的组蛋白H3乙酰化和DNA甲基化。我们的数据还表明，介导DNA甲基化和组蛋白乙酰化的酶协同调节E2对记忆巩固的影响。这些发现揭示了影响认知功能激素调节的表观遗传机制，并可能对理解激素如何影响成年和衰老的认知具有重要意义。本文将简要介绍表观遗传学和记忆的文献，详细描述我们的研究结果表明，表观遗传学改变调节E2诱导的记忆增强雌性小鼠，并讨论未来的研究方向E2诱导的记忆增强的表观遗传学调节。
Epigenetic alterations of histone proteins and DNA are essential for hippocampal synaptic plasticity and cognitive function, and contribute to the etiology of psychiatric disorders and neurodegenerative diseases. Hippocampal memory formation depends on histone alterations and DNA methylation, and increasing evidence suggests that regulation of these epigenetic processes by modulatory factors such as environmental enrichment, stress, and hormones substantially influences memory function. Recent work from our laboratory suggests that the ability of the sex-steroid hormone 17β-estradiol (E2) to enhance novel object recognition memory consolidation in young adult female mice is dependent on histone H3 acetylation and DNA methylation in the dorsal hippocampus. Our data also suggest that enzymes mediating DNA methylation and histone acetylation work in concert to regulate the effects of E2 on memory consolidation. These findings shed light on the epigenetic mechanisms that influence hormonal modulation of cognitive function, and may have important implications for understanding how hormones influence cognition in adulthood and aging. This review will provide a brief overview of the literature on epigenetics and memory, describe in detail our findings demonstrating that epigenetic alterations regulate E2-induced memory enhancement in female mice, and discuss future directions for research on the epigenetic regulation of E2-induced memory enhancement.
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影响因子：
2.7
作者：
Day, Jeremy J;Sweatt, J David
通讯作者：
Sweatt, J David
DOI：
10.1111/j.1749-6632.2010.05529.x
发表时间：
2010-01-01
期刊：
REPRODUCTIVE AGING
影响因子：
--
作者：
Dumitriu, Dani;Rapp, Peter R.;Morrison, John H.
通讯作者：
Morrison, John H.
影响因子：
3.2
作者：
Bohacek, J.;Bearl, A. M.;Daniel, J. M.
通讯作者：
Daniel, J. M.
影响因子：
4.8
作者：
Daniel, JM;Hulst, JL;Berbling, JL
通讯作者：
Berbling, JL
影响因子：
3.5
作者：
Duff, SJ;Hampson, E
通讯作者：
Hampson, E