Effects of "Bu Shen Huo Xue Decoction" on the Endometrial Morphology and Expression of Leukaemia Inhibitory Factor in the Rat Uterus during the Oestrous Cycle.
Effects of "Bu Shen Huo Xue Decoction" on the Endometrial Morphology and Expression of Leukaemia Inhibitory Factor in the Rat Uterus during the Oestrous Cycle.
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DOI：
10.1155/2013/496036
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Jin Z
中科院分区：
文献类型：
--
作者：
Gong X;Yu Y;Tong Q;Ren Y;Jin Z
探讨补肾活血汤对辅助生殖的积极作用。本研究旨在评估BSHXD是否可以改善子宫内膜形态，并增加促性腺激素释放激素激动剂（GnRHa）长期方案诱导的大鼠模型在动情后期，动情间期，动情前期和发情期的LIF的表达。与GnRHa长方案组相比，补肾活血汤组子宫内膜厚度明显增加，MVD明显降低。此外，BSHXD组中LIF的表达显著升高。BSHXD组与对照组之间MVD和LIF表达无显著差异。提示补肾活血汤能改善GnRHa长方案诱导的大鼠动情周期子宫内膜发育，减少异常血管生成，增加受体性标志物的表达，从而使子宫内膜环境更适合雌性生殖。
The purpose of this study was to explore the positive effects of Bu Shen Huo Xue Decoction (BSHXF) on assisted reproduction. The study aimed to evaluate whether BSHXD could improve endometrial morphology and increase the expression of LIF in a gonadotrophin-releasing hormone agonists (GnRHa) long protocol-induced rat model during metestrus, diestrus, proestrus, and oestrus. The BSHXD group presented significantly increased endometrium thickness and decreased MVD compared with the GnRHa long protocol group. In addition, the expression of LIF was significantly higher in the BSHXD group. There were no significant differences between the control group and the BSHXD group in terms of MVD and LIF expression. These results suggested that BSHXD can improve the endometrium development, reduce the abnormal angiogenesis, and increase the expression of receptivity markers in a GnRHa long protocol-induced rat model during the oestrous cycle, which might result in an endometrial environment better suited for female reproduction.
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影响因子：
5.8
作者：
Mirkin, S;Nikas, G;Oehninger, S
通讯作者：
Oehninger, S
影响因子：
6.7
作者：
Murray, MJ;Meyer, WR;Fritz, MA
通讯作者：
Fritz, MA
影响因子：
15.9
作者：
LESSEY, BA;DAMJANOVICH, L;BUCK, CA
通讯作者：
BUCK, CA
影响因子：
4
作者：
Norwitz, Errol R
通讯作者：
Norwitz, Errol R
影响因子：
6.1
作者：
NOYES, N;LIU, HC;ROSENWAKS, Z
通讯作者：
ROSENWAKS, Z