Delivery Routes for COVID-19 Vaccines.
Delivery Routes for COVID-19 Vaccines.
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DOI：
10.3390/vaccines9050524
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发表时间：
2021-05-19
期刊：
影响因子：
7.8
通讯作者：
Lee HK
中科院分区：
文献类型：
--
作者：
Park JH;Lee HK
引起 COVID-19 的新型冠状病毒 SARS-CoV-2 已导致大流行，导致数百万人死亡。为了根除 SARS-CoV-2 并防止进一步感染，已经开发了许多候选疫苗。这些疫苗不仅包括传统的亚单位疫苗和减毒或灭活病毒疫苗，还包括核酸和病毒载体疫苗。与平台技术的多样性相反，疫苗的输送仅限于肌肉注射疫苗。尽管肌肉注射疫苗安全有效，但粘膜疫苗接种可以改善局部免疫反应，阻止病原体传播。然而，由于对粘膜免疫缺乏了解，加上对 COVID-19 疫苗的迫切需求，导致只能进行肌肉注射疫苗接种。在这篇综述中，我们总结了疫苗的历史、COVID-19疫苗技术的当前进展以及鼻内COVID-19疫苗的现状。未来的研究应基于该平台确定最有效的疫苗递送途径，并确定不同递送途径功效的机制。
The novel coronavirus, SARS-CoV-2, which causes COVID-19, has resulted in a pandemic with millions of deaths. To eradicate SARS-CoV-2 and prevent further infections, many vaccine candidates have been developed. These vaccines include not only traditional subunit vaccines and attenuated or inactivated viral vaccines but also nucleic acid and viral vector vaccines. In contrast to the diversity in the platform technology, the delivery of vaccines is limited to intramuscular vaccination. Although intramuscular vaccination is safe and effective, mucosal vaccination could improve the local immune responses that block the spread of pathogens. However, a lack of understanding of mucosal immunity combined with the urgent need for a COVID-19 vaccine has resulted in only intramuscular vaccinations. In this review, we summarize the history of vaccines, current progress in COVID-19 vaccine technology, and the status of intranasal COVID-19 vaccines. Future research should determine the most effective route for vaccine delivery based on the platform and determine the mechanisms that underlie the efficacy of different delivery routes.
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DOI：
10.4049/jimmunol.1601775
发表时间：
2017-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Boyaka PN
通讯作者：
Boyaka PN
免疫途径定义了疫苗介导的对SIV的保护的多种机制。
影响因子：
82.9
作者：
Ackerman ME;Das J;Pittala S;Broge T;Linde C;Suscovich TJ;Brown EP;Bradley T;Natarajan H;Lin S;Sassic JK;O'Keefe S;Mehta N;Goodman D;Sips M;Weiner JA;Tomaras GD;Haynes BF;Lauffenburger DA;Bailey-Kellogg C;Roederer M;Alter G
通讯作者：
Alter G
影响因子：
4.4
作者：
Davies, Brooke;Prier, Julia E.;Mackay, Laura K.
通讯作者：
Mackay, Laura K.
影响因子：
100.3
作者：
Chen, Zeyu;John Wherry, E.
通讯作者：
John Wherry, E.
影响因子：
46.9
作者：
Chua, Robert Lorenz;Lukassen, Soeren;Eils, Roland
通讯作者：
Eils, Roland