Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey.
Traditional and non-traditional treatments for autism spectrum disorder with seizures: an on-line survey.
复制标题
DOI：
10.1186/1471-2431-11-37
复制
发表时间：
2011-05-18
期刊：
影响因子：
2.4
通讯作者：
Adams JB
中科院分区：
文献类型：
--
作者：
Frye RE;Sreenivasula S;Adams JB
尽管自闭症谱系障碍（ASD）患者中癫痫发作、癫痫和异常脑电图的患病率很高，但关于ASD人群中癫痫发作治疗的相对有效性的信息很少。为了确定传统和非传统治疗对改善癫痫发作和影响其他与ASD相关的临床因素的有效性，我们开发了一个全面的在线癫痫发作调查。ASD支持团体的公告（通过电子邮件和网站）要求ASD儿童的父母完成在线调查。调查响应者选择两项调查之一来完成：一项是关于ASD患者和临床或亚临床癫痫发作或异常脑电图的治疗的调查，另一项是针对没有临床或亚临床癫痫发作或异常脑电图的ASD患者的对照调查。调查应答者评估了传统抗癫痫药物（AED）、非AED癫痫发作治疗和非传统ASD治疗对癫痫发作和其他临床因素（睡眠、沟通、行为、注意力和情绪）的感知效果，并列出了多达三种治疗副作用。733例癫痫发作儿童和290例对照儿童获得了答复。一般而言，AED被认为可以改善癫痫发作，但会恶化临床癫痫发作儿童的其他临床因素。丙戊酸、拉莫三嗪、左乙拉西坦和乙琥胺被认为是改善癫痫发作最多的药物，而在所有临床癫痫发作的儿童中，其他临床因素的恶化最少。传统的非AED癫痫发作和非传统治疗，作为一个群体，被认为是改善其他临床因素和癫痫发作，但癫痫发作的改善明显低于AED报告。某些传统的非AED治疗，特别是生酮饮食，被认为可以改善癫痫发作和其他临床因素。对于报告亚临床癫痫发作的ASD个体，其他临床因素被报告为AED恶化，而非AED传统癫痫发作和非传统治疗改善。据报道，与传统的非AED治疗相比，AED的副作用发生率更高。虽然这种基于调查的方法只提供有关父母对有效性的看法的信息，但这些信息可能有助于ASD患者选择癫痫治疗。
Despite the high prevalence of seizure, epilepsy and abnormal electroencephalograms in individuals with autism spectrum disorder (ASD), there is little information regarding the relative effectiveness of treatments for seizures in the ASD population. In order to determine the effectiveness of traditional and non-traditional treatments for improving seizures and influencing other clinical factor relevant to ASD, we developed a comprehensive on-line seizure survey. Announcements (by email and websites) by ASD support groups asked parents of children with ASD to complete the on-line surveys. Survey responders choose one of two surveys to complete: a survey about treatments for individuals with ASD and clinical or subclinical seizures or abnormal electroencephalograms, or a control survey for individuals with ASD without clinical or subclinical seizures or abnormal electroencephalograms. Survey responders rated the perceived effect of traditional antiepileptic drug (AED), non-AED seizure treatments and non-traditional ASD treatments on seizures and other clinical factors (sleep, communication, behavior, attention and mood), and listed up to three treatment side effects. Responses were obtained concerning 733 children with seizures and 290 controls. In general, AEDs were perceived to improve seizures but worsened other clinical factors for children with clinical seizure. Valproic acid, lamotrigine, levetiracetam and ethosuximide were perceived to improve seizures the most and worsen other clinical factors the least out of all AEDs in children with clinical seizures. Traditional non-AED seizure and non-traditional treatments, as a group, were perceived to improve other clinical factors and seizures but the perceived improvement in seizures was significantly less than that reported for AEDs. Certain traditional non-AED treatments, particularly the ketogenic diet, were perceived to improve both seizures and other clinical factors. For ASD individuals with reported subclinical seizures, other clinical factors were reported to be worsened by AEDs and improved by non-AED traditional seizure and non-traditional treatments. The rate of side effects was reportedly higher for AEDs compared to traditional non-AED treatments. Although this survey-based method only provides information regarding parental perceptions of effectiveness, this information may be helpful for selecting seizure treatments in individuals with ASD.
登录
查看更多内容
影响因子：
1.9
作者：
Frye, Richard E.;Butler, Ian;Papanicolaou, Andrew
通讯作者：
Papanicolaou, Andrew
影响因子：
8
作者：
Mandell, David S.;Morales, Knashawn H.;Polsky, Daniel E.
通讯作者：
Polsky, Daniel E.
影响因子：
1.7
作者：
Hara, Hitoshi
通讯作者：
Hara, Hitoshi
影响因子：
3.6
作者：
Frye RE;Rossignol DA
通讯作者：
Rossignol DA
影响因子：
2
作者：
Mohamed, Hoda E.;El-Swefy, Sahar E.;Abd El-Latif, Sally K.
通讯作者：
Abd El-Latif, Sally K.