A Supramolecular Approach for Enhanced Antibacterial Activity and Extended Shelf-life of Fluoroquinolone Drugs with Cucurbit[7]uril.
A Supramolecular Approach for Enhanced Antibacterial Activity and Extended Shelf-life of Fluoroquinolone Drugs with Cucurbit[7]uril.
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DOI：
10.1038/s41598-018-32312-6
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发表时间：
2018-09-17
影响因子：
4.6
通讯作者：
Mohanty J
中科院分区：
文献类型：
--
作者：
El-Sheshtawy HS;Chatterjee S;Assaf KI;Shinde MN;Nau WM;Mohanty J
研究了第三代氟醌达氟沙星（DOFL）与大环主体瓜环（CB 7）在不同pH值（~3.5、7.5和10）下的主客体相互作用. CB 7的加入使DOFL的荧光产率和荧光寿命提高，光稳定性也得到改善。DOFL的抗菌活性在CB 7的存在下增强，如针对四种病原菌所测试的;已发现针对B的最高活性。cereus和E. coli的活性，而对S.金黄色葡萄球菌和伤寒。另外两种第二代氟醌的抗菌活性，即，诺氟沙星和氧氟沙星，也已经研究了在不存在以及存在的CB 7，并与DOFL进行比较。在所有药物的情况下，在CB 7存在下，最小抑制浓度（MIC）降低3-5倍。在CB 7存在下，无论四种类型的细菌如何，氟醌药物的延长的保质期（随时间的抗菌活性）可以归因于其CB 7复合物的增强的光稳定性，其可以作为比未复合的DOFL具有更长有效期的更好的抗生素。
The host-guest interactions of a third-generation fluoroquinone, danofloxacin (DOFL), with the macrocyclic host cucurbit[7]uril (CB7) have been investigated at different pH values (~3.5, 7.5, and 10). The photophysical properties have been positively affected, that is, the fluorescence yield and lifetime increased, as well as the photostability of DOFL improved in the presence of CB7. The antibacterial activity of DOFL is enhanced in the presence of CB7, as tested against four pathogenic bacteria; highest activity has been found towards B. cereus and E. coli, and lower activity towards S. aureus and S. typhi. The antibacterial activity of two additional second-generation fluoroquinones, i.e., norfloxacin and ofloxacin, has also been investigated in the absence as well as the presence of CB7 and compared with that of DOFL. In case of all drugs, the minimum inhibitory concentration (MIC) was reduced 3–5 fold in the presence of CB7. The extended shelf-life (antibacterial activity over time) of the fluoroquinone drugs in the presence of CB7, irrespective of four types of bacteria, can be attributed to the enhanced photostability of their CB7 complexes, which can act as better antibiotics with a longer expiry date than uncomplexed DOFL.
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影响因子：
9.5
作者：
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通讯作者：
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DOI：
10.1016/j.jphotochem.2018.02.037
发表时间：
2018-05-01
影响因子：
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作者：
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影响因子：
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作者：
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用于抗菌调节的超分子抗生素开关
影响因子：
16.6
作者：
Bai, Haotian;Yuan, Huanxiang;Wang, Shu
通讯作者：
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