Methamphetamine and Ovarian Steroid Responsive Cells in the Posteriodorsal Medial Amygdala are Required for Methamphetamine-enhanced Proceptive Behaviors.
Methamphetamine and Ovarian Steroid Responsive Cells in the Posteriodorsal Medial Amygdala are Required for Methamphetamine-enhanced Proceptive Behaviors.
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DOI：
10.1038/srep39817
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发表时间：
2017-01-03
影响因子：
4.6
通讯作者：
Mong JA
中科院分区：
文献类型：
--
作者：
Williams KM;Mong JA
甲基苯丙胺（Methamphetamine）是一种精神兴奋剂，与男性和女性的性欲和冲动的增加密切相关。性动机的这些变化对妇女的影响更大，因为她们可能面临更大的意外怀孕负担，以及抑郁症等精神病合并症的风险增加。我们以前已经建立了一个啮齿动物模型的甲基诱导性动机的增加。使用这个模型，我们已经确定了后背内侧杏仁核（MePD）通过兴奋性毒性损伤的研究，作为一个必要的核甲基促进女性性动机。虽然损伤研究使我们深入了解可能是甲基行动目标的关键核，但这种方法并不能深入了解特定MePD神经元或参与甲基诱导的感受行为增加的神经回路的身份。使用DAUN 02灭活方法，最近建立的技术，用于消除行为相关的细胞群，我们提出的证据表明，卵巢类固醇/甲基反应细胞的MePD是必要的甲基诱导的促进的感受行为。这些发现形成了未来工作的基础，这将允许参与MePD对感受行为的调制的神经元亚型的分类，以及对女性性动机的神经回路的更强理解。
Methamphetamine (Meth) is a psychomotor stimulant strongly associated with increases in sexual drive and impulse in both men and women. These changes in sexual motivation have a greater impact on women due to their likelihood of facing the greater burden of unplanned pregnancies, as well as increased risk for psychiatric co-morbidities such as depression. We have previously established a rodent model of Meth-induced increases in sexual motivation. Using this model, we have identified the posteriodorsal medial amygdala (MePD) via excitotoxic lesion studies as a necessary nucleus in Meth-facilitated female sexual motivation. While lesion studies give us insight into key nuclei that may be targets of Meth action, such an approach does not give insight into the identity of the specific MePD neurons or neural circuitry involved in Meth-induced increases in proceptive behaviors. Using the DAUN02 inactivation method, a recently established technique for removing behaviorally relevant cell populations, we present evidence that the ovarian steroid/Meth responsive cells in the MePD are necessary for Meth-induced facilitation of proceptive behaviors. These findings form the basis for future work that will allow for the classification of neuronal subtypes involved in the MePD’s modulation of proceptive behavior as well as a stronger understanding of the neurocircuitry of female sexual motivation.
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影响因子：
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作者：
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通讯作者：
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DOI：
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